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This safety information outlines important warnings and precautions related to the use of sulfacetamide/sulfur. It is essential to review this information carefully and discuss any concerns with your healthcare provider.

• Severe Allergic Reactions: Sulfacetamide/sulfur, a sulfonamide antibiotic, can cause rare but severe allergic reactions, including blood disorders and skin conditions such as Stevens-Johnson syndrome (SJS) and systemic lupus erythematosus (SLE). Symptoms of SJS may involve skin reddening or peeling, painful rashes, and fluid-filled blisters. SLE symptoms can include rashes and joint pain. Seek immediate medical attention if you experience difficulty breathing, rashes, hives, or swelling of the face, lips, or mouth. Inform your healthcare team of any known allergies before starting this medication. Risk: Allergy to sulfonamides.

• Contraindications: Certain conditions indicate when sulfacetamide/sulfur should not be used due to potential health risks. Consult your healthcare provider if any of the following apply to you:

  • Existing kidney problems
  • Known allergy to sulfa medications

Ensure you communicate all relevant health information to your healthcare provider to safely use this medication.

When using Sumadan XLT, it's important to be aware of potential interactions with other medications and certain health conditions. This topical treatment, containing sulfacetamide sodium and sulfur, may interact with specific drugs and may not be suitable for individuals with certain medical issues.

Drug Interactions:

Sumadan XLT can interact moderately with the following topical medications:

• Adapalene
• Alitretinoin
• Bexarotene
• Clascoterone
• Isotretinoin
• Tazarotene
• Tretinoin
• Trifarotene

Combining Sumadan XLT with these medications may increase the risk of skin irritation or other side effects. It's advisable to consult your healthcare provider before using Sumadan XLT alongside any of these treatments.

Disease Interactions:

Individuals with the following conditions should exercise caution or avoid using Sumadan XLT:

• Hematologic toxicity
• Hypersensitivity reactions
• Porphyria
• Crystalluria
• Liver disease
• Renal dysfunction
• Urinary obstruction

If you have any of these conditions, discuss with your doctor whether Sumadan XLT is appropriate for you.

General Precautions:

• Allergies: Do not use Sumadan XLT if you are allergic to sulfonamides (sulfa drugs), sulfur, or any other component of the product.
• Kidney Disease: Avoid using Sumadan XLT if you have kidney disease.
• Skin Sensitivity: If you experience skin irritation, redness, or scaling, discontinue use and consult your healthcare provider.

Always inform your doctor about all medications you are currently taking, including over-the-counter drugs and supplements, to prevent potential interactions. Your healthcare provider can provide personalized advice based on your medical history and current treatments.