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You may experience some common side effects such as nausea, vomiting, heartburn, headache, dizziness, trouble sleeping, appetite changes, increased sweating, or acne. These are usually mild, but if they persist or worsen, it's important to discuss them with your healthcare provider.

This medication can cause your blood sugar levels to rise, potentially leading to or worsening diabetes. Be vigilant for symptoms like increased thirst or frequent urination. If you have diabetes, monitor your blood sugar levels regularly and consult your healthcare provider for any necessary adjustments to your treatment plan.

There is a risk of this medication reducing your ability to fight infections, which can sometimes lead to severe infections. It's crucial to contact your healthcare provider if you notice symptoms such as a persistent sore throat, fever, chills, cough, or white patches in your mouth.

Serious side effects that require immediate attention include unusual weight gain, changes in menstrual periods, bone or joint pain, easy bruising or bleeding, mood changes, muscle weakness, swelling, slow wound healing, skin changes, vision problems, or irregular heartbeat. Additionally, symptoms of stomach bleeding, such as abdominal pain, black stools, or vomit resembling coffee grounds, should be addressed promptly.

Seek emergency medical attention if you experience seizures or signs of a severe allergic reaction, such as rash, itching, swelling, severe dizziness, or difficulty breathing. While serious allergic reactions are rare, they require immediate care.

This summary does not cover all possible side effects. If you notice any other unusual symptoms, contact your healthcare provider for further advice.

Certain medications and products can interact with this drug. These include aldesleukin, Desmopressin, and Mifepristone, as well as other medications that may increase the risk of bleeding or bruising. These can be antiplatelet drugs like Clopidogrel, blood thinners such as Warfarin or Dabigatran, and non-steroidal anti-inflammatory drugs (NSAIDs) like Ibuprofen, Celecoxib, Aspirin, and salicylates. If your doctor has advised you to take low-dose aspirin to help prevent heart attacks or strokes (typically 81-162 milligrams daily), continue taking it unless instructed otherwise by your doctor. Consult your doctor or pharmacist for further information.

Additionally, some medications can affect how your body processes methylprednisolone, which may impact its effectiveness. These include azole antifungals (e.g., Ketoconazole), Cyclosporine, estrogens, HIV protease inhibitors (such as Darunavir), macrolide antibiotics (like Erythromycin), Ritonavir, St. John's wort, and certain seizure medications (such as Phenytoin and Phenobarbital).

This drug might also interfere with specific laboratory tests, such as skin tests, leading to inaccurate results. Ensure that your doctors and the laboratory staff are aware that you are using this medication.