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You may experience some mild side effects like nausea, heartburn, headache, dizziness, changes in your menstrual cycle, trouble sleeping, increased sweating, or acne. These usually aren't cause for concern, but if they persist or worsen, it's important to consult your healthcare provider.

While taking this medication, your immune system may become less effective, which can increase the risk of infections. Be vigilant for signs such as a cough, sore throat, fever, or chills, and contact your doctor if they occur. Long-term use may lead to oral thrush or a yeast infection, so watch for white patches in your mouth or changes in vaginal discharge.

This medication can also raise blood sugar levels, potentially affecting those with diabetes. Symptoms like increased thirst or urination should be reported to your doctor. Regular blood sugar monitoring is advised, and adjustments to your diabetes management plan may be necessary.

Serious side effects require prompt medical attention. These include unusual tiredness, swelling in the ankles or feet, significant weight gain, vision changes, easy bruising or bleeding, facial puffiness, unusual hair growth, mood changes, muscle pain, thinning skin, slow wound healing, bone pain, stomach pain, black stools, vomit resembling coffee grounds, or skin discoloration.

In rare cases, severe side effects such as chest pain or seizures may occur, needing immediate medical intervention. Also, any signs of a severe allergic reaction, like rash, swelling, severe dizziness, or breathing difficulties, require urgent care. Always stay alert for other unexpected effects and discuss them with your healthcare provider.

Certain medications and products can interact with this drug, potentially affecting its effectiveness or your health. These include aldesleukin, desmopressin, and medications that suppress the immune system, like azathioprine, cyclosporine, and cancer chemotherapy treatments. Additionally, mifepristone, and drugs that increase the risk of bleeding or bruising, such as antiplatelet drugs like clopidogrel, anticoagulants like dabigatran or warfarin, and NSAIDs like aspirin, celecoxib, or ibuprofen, should be considered.

Some substances can alter how prednisolone is processed by your body, impacting its effectiveness. These include estrogen, azole antifungal medications like itraconazole, St. John's wort, and certain seizure medications like phenytoin.

If your healthcare provider has advised you to take low-dose aspirin (81-162 milligrams daily) to prevent heart attacks or strokes, continue doing so unless otherwise directed by your doctor. For more detailed advice, consult your doctor or pharmacist.

Moreover, this drug might affect the results of certain lab tests, such as skin tests, leading to inaccurate outcomes. Inform lab technicians and all your healthcare providers that you are using this medication.