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The following safety information outlines the potential risks and precautions associated with the use of desoximetasone (Topicort). Please read these details carefully and consult your healthcare provider if you have any questions or concerns.

• Altered Stress Hormone Levels: Under certain conditions, such as applying desoximetasone (Topicort) to large skin areas, using it for extended periods, or covering treated areas with occlusive dressings, your body may absorb excessive amounts of the drug. This can lead to a decrease in the production of stress hormones like cortisol, potentially causing symptoms such as fatigue, nausea, and muscle pain. These symptoms generally resolve upon discontinuation of the medication, though severe cases may require further treatment. Be cautious if you have liver problems, are applying to damaged skin or are using multiple topical steroids. Special care should be taken with young children.

• Vision Problems: While uncommon, the use of desoximetasone (Topicort) can increase the risk of developing eye conditions such as cataracts and glaucoma. Inform your healthcare provider if you have a history of vision problems or eye conditions before starting treatment. If you experience any changes in vision while using this medication, contact your healthcare provider or an eye specialist promptly.

• Flammability (Topical Spray Only): The topical spray form of desoximetasone is flammable. It is important to keep the spray bottle away from heat sources and open flames to prevent fire hazards.

There are no specific contraindications for desoximetasone (Topicort) provided in the available data. Always follow your healthcare provider's guidance when using this medication.

When using this medication, some individuals may experience mild side effects such as skin irritation, dryness, itching, burning sensations, or skin redness. These effects are generally not severe and often improve over time. However, if they persist or worsen, it is advisable to consult with a healthcare professional for further guidance.

In some cases, more serious side effects can occur, though they are less common. These include stretch marks, skin thinning or discoloration, acne, excessive hair growth, or small red bumps on the skin known as folliculitis. If you notice any of these symptoms, it is important to seek medical advice promptly.

On rare occasions, the medication may be absorbed into the bloodstream, particularly if used over large areas or for extended periods. This can result in symptoms such as unusual or extreme tiredness, weight loss, headaches, swelling in the ankles or feet, increased thirst or urination, and vision problems. These are more likely to occur in children. If you experience these symptoms, seek medical attention immediately.

Additionally, although rare, a severe allergic reaction may occur. Symptoms may include a rash, swelling, severe dizziness, or difficulty breathing. Seek emergency medical help if these occur. It's important to remember that this list does not cover all potential side effects, so if you notice any other unusual symptoms, consult your healthcare provider.