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This document outlines important safety information related to the use of desoximetasone (Topicort). It is crucial to understand potential risks and follow precautions to ensure safe use. Consult your healthcare provider with any questions or concerns.

• Altered Stress Hormone Levels: Excessive absorption of desoximetasone through the skin can occur when the medication is used over large skin areas, for prolonged periods, or if the treated area is covered with tight bandages. This can lead to decreased production of stress hormones, such as cortisol, resulting in symptoms like fatigue, nausea, and muscle pain. Symptoms typically resolve upon discontinuation of the medication, but severe cases may require further treatment. Be cautious if you have liver problems, are applying to damaged skin, or are a young child.

• Vision Problems: Desoximetasone can potentially increase the risk of cataracts and glaucoma. Ensure your healthcare provider is aware of any pre-existing eye conditions before beginning treatment. Report any new vision issues to your healthcare team promptly.

• Flammability (Topical Spray Only): The topical spray form of desoximetasone is flammable. Keep it away from heat sources and open flames.

By adhering to these guidelines, you can minimize risks and ensure the effective use of desoximetasone.

Common side effects:

• burning
• itching
• irritation
• dryness

Less common but important to monitor:

• stretch marks
• skin thinning
• skin discoloration
• acne
• excessive hair growth
• small red bumps (folliculitis)
• worsening skin infections
• persistent redness, swelling, or irritation

Serious side effects:

• unusual or extreme tiredness
• weight loss
• headaches
• swelling of ankles or feet
• increased thirst or urination
• vision problems
• rash, itching, or swelling of face, tongue, or throat
• severe dizziness
• difficulty breathing

Desoximetasone is a topical corticosteroid used to treat various skin conditions. While it is applied to the skin, some of the medication can be absorbed into the bloodstream, potentially leading to interactions with other medications or health conditions.

Drug Interactions:

• Immunosuppressants: Using desoximetasone alongside immunosuppressant medications like ciclosporin may increase the risk of adverse effects.

• Other Corticosteroids: Combining desoximetasone with other corticosteroids, such as Prednisone, can enhance the effects of both drugs, potentially leading to increased side effects.

• Diabetes Medications: Desoximetasone may interfere with blood sugar control, reducing the effectiveness of diabetes medications like Metformin and insulin. This is particularly important when desoximetasone is used over large areas of the skin, for prolonged periods, or under occlusive dressings.

Disease Interactions:

• Diabetes: Desoximetasone can raise blood glucose levels by affecting insulin action and secretion. Individuals with diabetes should use this medication cautiously and monitor their blood sugar levels regularly.

• Skin Infections: Applying desoximetasone to infected skin areas may worsen the infection. It's important to inform your doctor if you have any skin infections before using this medication.

• Liver Conditions: People with liver problems may experience increased side effects from desoximetasone due to altered drug metabolism.

Other Considerations:

• Alcohol: The interaction between desoximetasone and alcohol is not well understood. It's advisable to consult your doctor before consuming alcohol while using this medication.

• Pregnancy and Breastfeeding: Desoximetasone is classified as a Category C drug for pregnancy, meaning it should only be used if the potential benefits justify the potential risks. If prescribed during breastfeeding, avoid applying the medication to the breast area to prevent accidental ingestion by the infant.

Always inform your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements, to avoid potential interactions. Do not use desoximetasone with other topical corticosteroids unless directed by your doctor, as this can increase the risk of side effects.