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This information outlines the critical safety warnings and precautions associated with the use of Toujeo (insulin glargine). It is essential for patients and healthcare providers to review these details to ensure safe use of the medication.

• Infection Risk from Pen Sharing: Do not share Toujeo (insulin glargine) pens, syringes, or needles with anyone. Sharing can transmit severe infections and health issues.

• Low Blood Sugar (Hypoglycemia): Using Toujeo (insulin glargine) can lead to dangerously low blood sugar levels, especially when taken with other diabetes medications. To avoid hypoglycemia, verify the labels on all diabetes medications to ensure correct usage. Factors that can increase risk include dietary changes, alcohol consumption, additional diabetes drugs, liver or kidney issues, and incorrect usage.

• Low Blood Potassium Levels: Toujeo (insulin glargine) may decrease potassium levels in the blood, which can be hazardous. The risk is higher if you are using other medications that also reduce potassium, such as certain diuretics. Healthcare providers may monitor potassium levels and prescribe supplements if necessary.

• Fluid Retention and Heart Failure Risk: Combining Toujeo (insulin glargine) with glitazones (e.g., pioglitazone) can cause fluid retention, potentially leading to or exacerbating heart failure. Symptoms include difficulty breathing and reduced exercise capacity. This risk is heightened in individuals with a history of heart failure.

• Allergic Reactions: Though rare, Toujeo (insulin glargine) may cause severe allergic reactions, such as anaphylaxis. Seek immediate medical attention if you experience symptoms like facial swelling, rash, or breathing difficulties.

Contraindications:

• Hypoglycemia Episodes: Do not use Toujeo (insulin glargine) during low blood sugar episodes.

• Allergy to Insulin Glargine: Avoid use if you have allergies to insulin glargine products, including Lantus, Basaglar, or Semglee.

Consult with a healthcare provider if you have any concerns or questions about using Toujeo (insulin glargine) safely.

When using this medication, some individuals may experience common side effects that are generally mild, such as injection site reactions like pain, redness, or irritation, and weight gain. These are usually manageable, but if they persist or worsen, discussing them with your healthcare provider is advisable. Additionally, symptoms resembling a common cold or infections involving the nose, throat, and lungs may occur.

More concerning side effects, though rare, require serious attention. These include signs of low potassium, such as muscle cramps, weakness, or an irregular heartbeat. Low blood sugar, or hypoglycemia, may present with symptoms like sudden sweating, shaking, rapid heartbeat, hunger, blurred vision, dizziness, or tingling in the hands and feet. It is important to manage blood sugar levels by consuming regular meals and having glucose tablets or quick sources of sugar on hand during episodes of low blood sugar.

In some cases, high blood sugar, or hyperglycemia, may develop, indicated by increased thirst and urination. Severe allergic reactions, though uncommon, are serious and include symptoms like rash, hives, swelling of the face, tongue, and throat, and difficulty breathing. Immediate medical attention is necessary if these occur. Always report any unexplained or severe side effects to your healthcare provider for further guidance.