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This medication carries several important safety considerations that both patients and healthcare providers should be aware of. Carefully review the following points and consult with your healthcare provider for any concerns or questions.

• Thyroid Cancer Risk: Studies in animals suggest that this medication, such as Rybelsus (semaglutide), may increase the risk of developing thyroid cancer, specifically thyroid C-cell tumors. It is not yet confirmed if this risk extends to humans. You should not use this medication if you or any family members have a history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2). Contact your healthcare provider immediately if you experience any symptoms such as lumps or unusual growths in the neck, difficulty swallowing, persistent hoarseness, or shortness of breath.

• Pancreatitis: Although rare, some individuals using Rybelsus (semaglutide) have developed inflammation of the pancreas. Severe abdominal or back pain, or persistent vomiting, should be reported to your healthcare provider promptly.

• Eye Complications: There is a risk of worsening diabetic retinopathy for those on this medication. Any changes in vision should be immediately discussed with your healthcare provider.

• Hypoglycemia: When combined with other medications that increase insulin levels, such as sulfonylureas or insulins, there is a heightened risk of low blood sugar. Be aware of symptoms like shaking, confusion, sweating, dizziness, or blurred vision, and consult your provider to possibly adjust your medication dosage.

• Dehydration and Kidney Concerns: Side effects that affect the stomach may lead to dehydration in some users. Symptoms of dehydration include excessive thirst, dry skin, and reduced urination. Monitor these signs closely.

• Severe Allergic Reactions: Some individuals may experience severe allergic reactions, including anaphylaxis, characterized by facial swelling, hives, or difficulty breathing. Seek immediate medical attention if these occur.

• Gallbladder Issues: Although uncommon, gallstones and gallbladder inflammation have been reported. Symptoms like upper abdominal pain, fever, or clay-colored stools should be promptly communicated to your healthcare provider.

Contraindications: This medication is contraindicated for individuals with a personal or family history of medullary thyroid carcinoma or those diagnosed with multiple endocrine neoplasia syndrome type 2 (MEN 2). Always consult your healthcare provider if these conditions apply to you before starting this medication.

When taking semaglutide, it's important to be aware of potential side effects. Commonly, patients might experience nausea, stomach pain, diarrhea, reduced appetite, vomiting, or constipation. These are usually mild and tend to improve over time. However, if they persist or worsen, consulting a healthcare provider is advisable. Other less common side effects may include bloating, indigestion, gas, acid reflux, and stomach inflammation. It's important to monitor for signs of low blood sugar, such as dizziness, sweating, or shaking, particularly if semaglutide is used with other diabetes medications.

Serious side effects, although rare, require immediate medical attention. These include symptoms of thyroid cancer, like a neck mass or difficulty breathing, and pancreatitis, which presents as persistent stomach or back pain. Kidney issues might manifest as changes in urine output or swelling in the ankles, while gallbladder problems could cause upper stomach pain or jaundice. Low blood sugar symptoms, such as confusion or blurred vision, are also serious. Lastly, severe allergic reactions, indicated by breathing difficulties or swelling, necessitate urgent care.

It's crucial to stay informed about these potential side effects and to maintain regular communication with your healthcare provider to manage any adverse effects effectively.