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This medication carries important safety and warning information that must be carefully considered by patients and healthcare professionals. Below are critical points to keep in mind:

• Pregnancy Warning: This medication is contraindicated during pregnancy due to the risk of severe harm to an unborn child. Patients who can become pregnant must enroll in the Tryvio REMS program, which ensures the medication is used safely. Reliable birth control must be used before starting, during, and for one month after treatment. A pregnancy test is required before beginning the treatment. If you become pregnant or suspect pregnancy, inform your healthcare provider immediately.

• Liver Health: This medication can cause elevated liver enzyme levels, indicating potential liver injury. Regular medical appointments and blood tests are essential to monitor liver function. Seek immediate medical attention if you experience symptoms such as nausea, vomiting, upper abdominal pain, dark urine, loss of appetite, fatigue, fever, or jaundice.

• Fluid Retention: The use of this medication may lead to fluid retention, causing swelling or shortness of breath. This can exacerbate heart failure, especially in patients with pre-existing heart conditions. Inform your healthcare provider if you have a history of heart problems before starting this medication.

• Anemia Risk: The medication may lower hemoglobin levels, potentially causing anemia. If you have a history of anemia, discuss with your healthcare provider whether this treatment is appropriate for you.

• Effects on Male Fertility: This medication may reduce sperm count in males, possibly affecting future fertility. If you plan to have children, discuss alternative treatment options with your healthcare provider, as it is unclear whether the effect is reversible after discontinuation.

• Contraindications: This medication should not be used if you are currently pregnant. Always consult your healthcare provider if you have any concerns or if any contraindications apply to your situation.

Always follow your healthcare provider's advice and report any unusual symptoms or concerns immediately.

When taking this medication, it's important to be aware of potential side effects, although many individuals experience few or mild issues. Common side effects include edema, characterized by fluid buildup and swelling, occurring in about 9% of users, and anemia, which affects around 4%. These conditions may cause symptoms like tiredness and shortness of breath, but they are generally manageable. If these symptoms persist or worsen, consulting a healthcare provider is advisable.

Some users might experience more severe side effects, which require closer attention. These include fluid buildup leading to shortness of breath, swelling in the legs, or unusual weight gain, and signs of liver injury like loss of appetite, nausea, vomiting, and yellowing of the skin or eyes. Anemia can also present symptoms such as dizziness and irregular heartbeat. In rare instances, a serious allergic reaction may occur, marked by a rash, severe dizziness, or trouble breathing. Immediate medical care is essential if these severe reactions arise.

While these side effects can be concerning, it is important to remember that they are rare, and many people do not experience them at all. Always stay informed and consult healthcare professionals if you notice any unusual symptoms.