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It is crucial to be aware of the safety information and warnings associated with the use of this medication. Please review the following details carefully and consult your healthcare provider if you have any questions or concerns.

• Smoking and Cardiovascular Risks: If you smoke and are 35 years or older, using hormonal contraceptives like Safyral increases your risk of severe cardiovascular events, including strokes, heart attacks, and blood clots. It is advisable to discuss alternative birth control methods with your healthcare provider.

• Blood Clot Risks: Safyral can elevate the risk of developing blood clots in various parts of the body, such as the lungs, legs, brain, and heart. Immediate medical attention is required if you experience symptoms indicative of a blood clot. Increased risk factors include smoking (especially over the age of 35), recent surgery, postpartum phase, high blood pressure, obesity, diabetes, and higher estrogen doses.

• Cancer Risks: Although research is mixed, there may be a heightened risk of breast and cervical cancer with prolonged use of Safyral. Those with a history of breast cancer or long-term use of combined oral contraceptives should exercise caution.

• Liver Concerns: Safyral might cause liver issues, including liver damage and tumors, especially in formulations with higher estrogen levels. Individuals with pre-existing liver conditions or those using high-estrogen COCs for extended periods should be particularly cautious.

• Blood Pressure: The use of Safyral can lead to increased blood pressure. Regular monitoring is recommended, and those with uncontrolled hypertension should consider alternative contraceptive options.

• Blood Sugar and Lipid Levels: Safyral may raise blood sugar and triglyceride levels, potentially leading to complications. Individuals with diabetes or a history of high triglycerides should monitor their levels closely.

• Headaches and Depression: Common side effects include headaches and potential mood changes. Seek medical advice if experiencing severe headaches or symptoms of depression.

• Drug Interactions: Certain medications can alter the effectiveness of Safyral, either reducing its efficacy or increasing side effects. It is essential to inform your healthcare provider of all medications you are taking.

• Potassium Levels: Safyral contains drospirenone, which may increase potassium levels, especially when taken with other potassium-raising medications. Monitoring is advised for those with kidney, liver, or adrenal issues.

Contraindications: This medication should not be used if you have any of the following conditions, as it may pose serious health risks:

• Kidney, liver, or adrenal problems
• Age over 35 and smoking
• High risk of blood clots
• Vascular issues affecting the heart or brain
• Unexplained abnormal uterine bleeding
• Certain heart conditions
• Uncontrolled hypertension or diabetes
• Pregnancy
• Current or past breast cancer
• Severe headaches involving the brain or spine
• Migraines with aura in individuals over 35
• Liver tumors
• Current treatment with Viekira Pak

Always consult with your healthcare provider before starting or stopping any medication.

When taking this medication, some common side effects may occur, though they are generally mild and manageable. These include nausea, vomiting, headaches or migraines, abdominal cramps, bloating, breast tenderness, and fluid retention leading to swelling of the ankles or feet. You might also notice changes in weight, premenstrual syndrome symptoms, or irregular menstrual bleeding, especially during the initial months of use. While these side effects are typically not serious, if they persist or become bothersome, it is advisable to consult your healthcare provider.

It is important to monitor your blood pressure, as this medication can cause an increase. If you experience symptoms such as mood changes or depression, or unusual changes in vaginal bleeding, it's crucial to inform your healthcare provider. Serious side effects, although rare, demand immediate medical attention. These include symptoms of a heart attack, such as chest pain or dizziness, signs of a stroke like sudden weakness or difficulty speaking, and indications of blood clots, such as pain and swelling in the legs or difficulty breathing.

Additionally, be aware of potential liver problems, which can manifest as yellowing skin or eyes, and serious allergic reactions, characterized by rash or trouble breathing. If you experience any of these severe symptoms, seek urgent medical care. Remember, this is not an exhaustive list of side effects, so keep your healthcare provider informed of any other unusual symptoms.

Certain medications can interact with this drug, so it's important to be aware of these potential issues. Some drugs, like aromatase inhibitors (anastrozole, exemestane, letrozole), atazanavir/cobicistat, fezolinetant, ospemifene, tamoxifen, and tranexamic acid, may interact with it. Additionally, drospirenone in this medication can increase potassium levels in your blood. If you're taking other medications that also elevate potassium, such as aliskiren, ACE inhibitors (benazepril, lisinopril), angiotensin receptor blockers (losartan, valsartan), heparin, NSAIDs (ibuprofen, naproxen), or potassium-sparing diuretics (spironolactone, triamterene), inform your doctor.

Some medications can reduce the effectiveness of hormonal birth control by lowering hormone levels, which may lead to pregnancy. These include griseofulvin, modafinil, rifamycins (rifampin, rifabutin), ritonavir, St. John's wort, certain seizure medications (barbiturates, carbamazepine, felbamate, phenytoin, primidone, topiramate), and certain HIV drugs (nelfinavir, nevirapine). Always inform your doctor when starting a new medication and discuss whether you need additional reliable birth control methods. If you notice new spotting or breakthrough bleeding, let your doctor know, as these could indicate your birth control is not fully effective.

Moreover, this medication might affect certain laboratory tests, such as those measuring blood clotting factors or thyroid function, potentially leading to inaccurate results. Ensure all healthcare providers and lab personnel are aware that you are taking this medication.