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Taking varenicline may lead to some common side effects such as nausea, headache, vomiting, drowsiness, gas, constipation, trouble sleeping, unusual dreams, or changes in taste. These effects are generally mild and tend to improve as your body adjusts to the medication. However, if they persist or worsen, it is advisable to consult your healthcare provider.

There are some serious side effects that require immediate medical attention. These include a burning sensation in the feet or toes and unusual pain in the legs while walking. It is crucial to stop taking varenicline and seek urgent medical help if you experience seizures, heart attack symptoms (such as chest pain, pain in the jaw or left arm, shortness of breath, or unusual sweating), or signs of a stroke (such as sudden weakness on one side of the body, trouble speaking, sudden vision changes, or confusion). Additionally, any harmful behavior towards yourself, others, or property should be addressed immediately.

Varenicline can cause significant mental or mood changes, even after discontinuing the medication. This risk may be heightened by alcohol consumption or the process of quitting smoking. Be vigilant for symptoms like depression, suicidal thoughts, agitation, aggression, or other unusual behaviors, and stop the medication, informing your healthcare provider promptly.

Although rare, serious allergic reactions to varenicline can occur. Seek immediate medical assistance if you notice symptoms such as rash, itching, swelling (particularly of the face, tongue, or throat), severe dizziness, or difficulty breathing. This summary does not encompass all potential side effects—if you notice other unusual symptoms, contact your healthcare provider for advice.