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The following safety information highlights crucial warnings associated with the use of icosapent ethyl (Vascepa). It is vital to understand these risks and consult your healthcare provider if you have any questions or concerns.

• Heart Rhythm Issues: Icosapent ethyl (Vascepa) may increase the likelihood of developing irregular heart rhythms, such as atrial fibrillation or atrial flutter, which could necessitate hospitalization. Prior to using icosapent ethyl, inform your healthcare provider if you have a history of irregular heartbeats, heart disease, or diabetes with heart disease risk factors. Seek immediate medical advice if you experience symptoms like chest pain, dizziness, weakness, or shortness of breath.

• Allergic Reactions: As icosapent ethyl is derived from fish oil, individuals with fish or shellfish allergies may have an allergic reaction to this medication. It is important to disclose all allergies to your provider before beginning treatment, especially fish allergies. Discontinue use and seek emergency care if you develop hives, swelling of the lips or tongue, or breathing difficulties.

• Bleeding Risks: This medication can elevate the risk of bleeding, particularly if you are also taking anticoagulants (e.g., warfarin) or antiplatelet drugs (e.g., aspirin, clopidogrel). Urgent medical attention is needed if you encounter problems with bleeding cessation, blood in urine or stool, coughing up blood, or if you feel lightheaded or faint.

Please ensure to follow these guidelines and consult your healthcare provider for personalized advice tailored to your health needs.

Vascepa, a prescription medication used to lower high triglyceride levels, can interact with various other drugs, potentially affecting its efficacy or increasing the risk of side effects. It's crucial to be aware of these interactions to ensure safe and effective treatment.

Increased Bleeding Risk

Vascepa may increase the risk of bleeding, especially when taken with medications that affect blood clotting. These include:

• Anticoagulants: Medications like Warfarin, apixaban, and Rivaroxaban are used to prevent blood clots. Combining these with Vascepa can further elevate bleeding risk.

• Antiplatelet Agents: Drugs such as Aspirin, Clopidogrel, and Ticagrelor help prevent platelets from clumping together. Taking these alongside Vascepa can also increase bleeding tendencies.

If you're on any of these medications, your doctor may monitor you more closely for signs of bleeding, such as unusual bruising, prolonged bleeding from cuts, or blood in your urine or stools.

Potential for Atrial Fibrillation or Flutter

In some cases, Vascepa has been associated with an increased risk of atrial fibrillation or atrial flutter, especially in individuals with a history of these conditions. Symptoms may include palpitations, dizziness, or shortness of breath. If you experience any of these, contact your healthcare provider promptly.

Allergic Reactions in Individuals with Fish Allergies

Vascepa contains eicosapentaenoic acid (EPA), derived from fish oil. While it's not confirmed whether individuals with fish or shellfish allergies are at increased risk, it's advisable to inform your doctor if you have such allergies. Monitor for signs of an allergic reaction, including rash, itching, swelling, or difficulty breathing, and seek medical attention if they occur.

Interactions with Other Medications

Certain drugs may reduce the effectiveness of Vascepa or increase the risk of side effects:

• Beta-Blockers: Medications like Propranolol and metoprolol, used for high blood pressure and heart conditions, may diminish Vascepa's effectiveness.

• Thiazide Diuretics: Drugs such as Hydrochlorothiazide, used to treat high blood pressure, can also reduce Vascepa's efficacy.

• Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Over-the-counter pain relievers like Ibuprofen and Naproxen can increase bleeding risk when taken with Vascepa.

Alcohol Consumption

While no direct interaction between Vascepa and alcohol has been identified, excessive alcohol intake can raise triglyceride levels, counteracting Vascepa's benefits. It's advisable to limit alcohol consumption during treatment.

Recommendations

Before starting Vascepa, inform your healthcare provider about all medications, supplements, and over-the-counter drugs you are taking. This will help them assess potential interactions and adjust your treatment plan accordingly. Regular monitoring and open communication with your doctor are essential to ensure the safe and effective use of Vascepa.