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The safety information below highlights crucial warnings and potential risks associated with the use of this medication. It is essential to thoroughly review these details and discuss any concerns with your healthcare provider.

• Liver Damage: Fenofibrate can cause severe liver damage, potentially leading to liver failure and death. Liver damage may occur anytime during treatment but could resolve after discontinuation. Regular blood tests are necessary to monitor liver health before and during treatment. If you have abnormal lab results or symptoms such as abdominal swelling, pain, nausea, vomiting, jaundice, changes in stool, or confusion, you may need to stop the medication. This drug is contraindicated for those with existing liver conditions. Immediate medical attention is required if liver problems are suspected. Increased risk is associated with higher doses of fenofibrate.

• Muscle Damage (Myopathy and Rhabdomyolysis): Fenofibrate may increase the risk of muscle damage, which, if severe, can lead to rhabdomyolysis and subsequent organ damage. The risk is heightened if you are taking other muscle-affecting medications like statins or if you have certain conditions such as diabetes. Prior consultation with your provider is essential if you are on other medications that may cause muscle damage. Seek immediate medical help if you experience fever, sudden muscle pain, cramps, weakness, or dark-colored urine. Those at higher risk include older adults, individuals with kidney failure, diabetes, or hypothyroidism, and those on other muscle-damaging drugs.

• Kidney Effects: Fenofibrate may cause increased creatinine levels, indicating potential kidney damage. Although the precise impact on kidneys is unclear, starting at a lower dose and regular kidney function tests may be advised. Those over 65, with diabetes, or existing kidney issues are at greater risk. Report changes in urination or dark urine to your provider.

• Allergic Reactions: Allergic reactions to fenofibrate, potentially life-threatening, may occur. Symptoms include mouth or facial swelling and anaphylaxis. Stop the medication and seek immediate medical attention if you experience hives, lip or tongue swelling, or breathing difficulties.

• Gallstones: Fenofibrate can increase the risk of gallstones, contraindicating its use in individuals with gallbladder issues. Report symptoms such as stomach or back pain, nausea, or vomiting to your healthcare provider promptly.

• Pancreatitis: Rarely, fenofibrate can cause pancreatitis, possibly linked to high triglyceride levels or the drug itself. Symptoms include sudden stomach pain, nausea, vomiting, or abdominal fluid buildup. Contact your provider if these occur.

• Blood Clots: The medication may elevate the risk of blood clots, such as pulmonary embolism or deep vein thrombosis. If you experience chest pain, breathing difficulty, leg swelling, or warm, tender skin, seek medical help immediately.

Contraindications: Avoid using this medication in the presence of the following conditions, as it may pose significant health risks:

• Severe kidney disease or dialysis
• Liver disease
• Gallbladder disease
• Nursing mothers

Consult your healthcare provider if any of these conditions apply to you before starting this medication.

When taking this medication, it's important to be aware of potential side effects. Commonly reported mild side effects include stomach pain, liver damage, and lung problems, though they generally don't cause serious harm. Some individuals may also experience back pain, headache, stuffy nose, nausea, constipation, or a rash. These symptoms are usually manageable, but if they persist, consult your healthcare provider for guidance.

However, some side effects can be more severe and require immediate medical attention. Though rare, this medication may cause significant liver issues, which might manifest as yellowing of the skin or eyes, swelling of the stomach, or persistent nausea and vomiting. Additionally, serious muscle problems could occur, potentially leading to a condition called rhabdomyolysis, characterized by muscle pain, weakness, fever, and dark urine. There is also a risk of blood clots forming in the lungs or legs, presenting with chest pain, difficulty breathing, or swelling and warmth in the legs.

Severe allergic reactions are also possible, although infrequent. Symptoms such as rash, itching, swelling, severe dizziness, or trouble breathing require urgent medical help. Keep track of any unusual symptoms and seek professional advice if you notice anything concerning. Regular lab tests may be recommended to monitor your health while on this medication. Always communicate with your healthcare provider about any changes in your condition.

Certain medications can interact with Fenofibric acid, so it is important to be aware of these potential interactions. For instance, combining Fenofibric acid with "blood thinners" such as warfarin is not advised due to the increased risk of bleeding. Fenofibric acid is closely related to fenofibrate, and therefore, you should avoid using fenofibrate-containing medications while taking Fenofibric acid.

Additionally, certain medications like Ciprofibrate should not be used with Fenofibric acid, as this combination is generally not recommended. There are also drugs, such as Acenocoumarol, Anisindione, and various statins (including Atorvastatin and Lovastatin), that are usually advised against being used together with Fenofibric acid unless specifically prescribed by your doctor. In such cases, your doctor might adjust the dosage or frequency of one or both medications.

Furthermore, some medications, like Colestipol, Cyclosporine, and Ezetimibe, might increase the risk of side effects when used with Fenofibric acid. However, if the combined use of these medications is deemed necessary, your doctor may modify the dosing schedule to manage potential side effects effectively. Always inform your healthcare provider about all medications and supplements you are currently taking to ensure safe and effective treatment.