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The safety and warning information for gemfibrozil (Lopid) outlines important considerations to ensure safe usage. Please read the following points carefully and discuss any concerns with your healthcare provider:

• Gallstones Risk: Gemfibrozil (Lopid) may lead to the formation of gallstones. Contact your healthcare provider immediately if you notice symptoms such as stomach, back, or shoulder pain, nausea, vomiting, or yellowing of the eyes or skin. Avoid using gemfibrozil if you have a history of gallbladder issues.

• Drug Interactions: Gemfibrozil can interact with other medications, which may be dangerous. If you are taking the blood thinner warfarin (Coumadin), inform your healthcare provider or pharmacist, as this combination can increase bleeding risk. Regular blood monitoring is advised.

• Muscle Damage: There is a potential for muscle damage with gemfibrozil use, which can escalate to kidney damage or failure, particularly if combined with statin medications. Notify your healthcare provider if you experience sudden muscle pain, weakness, or dark-colored urine.

Contraindications for gemfibrozil include:

• Liver or Severe Kidney Conditions: Avoid using this medication if you have liver issues or severe kidney problems.

• Gallbladder Issues: Do not use gemfibrozil if you have gallbladder problems.

• Concurrent Medications: Do not take gemfibrozil if you are also using repaglinide, simvastatin (Zocor), dasabuvir, or Uptravi (selexipag), as these combinations may pose serious health risks.

Ensure to consult your healthcare provider if any of these contraindications apply to you.

Common side effects:

• stomach upset
• indigestion
• stomach pain
• diarrhea
• constipation
• unusual taste
• feeling tired
• headaches
• spinning sensation
• skin reactions like a rash

Serious side effects:

• severe stomach or abdominal pain
• persistent nausea or vomiting
• yellowing of the eyes or skin
• dark urine
• gallstones
• muscle problems leading to rhabdomyolysis
• muscle pain, tenderness, or weakness
• signs of infection
• easy bruising
• unusual tiredness
• irregular heartbeat
• numbness in the arms or legs
• serious allergic reactions
• rash, itching, swelling (especially of the face, tongue, or throat)
• severe dizziness
• trouble breathing

Interactions with high risk of serious adverse effects and should be avoided:

• Ciprofibrate
• Dasabuvir
• Elagolix
• Repaglinide
• Selexipag
• Simvastatin

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Amiodarone
• Apalutamide
• Atorvastatin
• Baricitinib
• Bexarotene
• Colchicine
• Dabrafenib
• Eluxadoline
• Enzalutamide
• Ezetimibe
• Fluvastatin
• Imatinib
• Lovastatin
• Ozanimod
• Pitavastatin
• Pravastatin
• Revefenacin
• Rosuvastatin
• Tucatinib

Interactions with low risk that usually do not require a change in therapy:

• Dicumarol
• Glipizide
• Glyburide
• Loperamide
• Lopinavir
• Montelukast
• Rosiglitazone
• Warfarin