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Whey protein isolate can have several drawbacks. Some individuals may experience digestive issues such as bloating, gas, or diarrhea, particularly if they are lactose intolerant, as whey protein is derived from milk. Additionally, some people may have allergies to whey protein. Overconsumption of protein supplements can also lead to kidney strain, especially in individuals with pre-existing kidney conditions. Furthermore, some whey protein products may contain added sugars, artificial flavors, or other additives that may not be desirable for everyone. It is important to choose a high-quality product and consult with a healthcare professional if there are any concerns.

Whey isolate is generally considered safe for most people when consumed in appropriate amounts. However, some individuals may experience side effects such as digestive issues, including bloating, gas, or diarrhea, particularly if they are lactose intolerant. It's important to note that whey isolate typically contains less lactose than other forms of whey protein, which may reduce the likelihood of these symptoms. Additionally, excessive consumption of protein supplements can lead to kidney strain or imbalances in nutrient intake. It's advisable to consult with a healthcare professional before starting any new supplement regimen.