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The safety information for ciprofloxacin (Cipro) is critical to ensure its safe and effective use. Below, you will find key warnings and precautions to consider before using this medication. Always consult your healthcare provider with any questions or concerns.

• Tendon Damage: Ciprofloxacin (Cipro), a quinolone antibiotic, can increase the risk of tendonitis and tendon rupture, primarily affecting the Achilles tendon but potentially impacting others like those in the shoulder and hand. This risk persists even after stopping the medication. Discontinue use and contact your healthcare provider if you notice joint or muscle pain or swelling. Higher risk groups include individuals over 60, those on corticosteroids, transplant recipients, high-intensity athletes, individuals with kidney failure, or those with a history of tendon issues such as rheumatoid arthritis.

• Neurological and Mental Health Effects: This medication may lead to seizures, dizziness, tremors, and nerve damage, which can manifest as pain, numbness, tingling, burning, or weakness. Those with a history of seizures, nerve issues, kidney problems, or those taking seizure-inducing medications are at increased risk.

• Myasthenia Gravis: Ciprofloxacin (Cipro) can exacerbate symptoms of myasthenia gravis, including muscle weakness and respiratory difficulties. Discuss alternative antibiotics with your healthcare provider if you have this condition.

• Allergic Reactions: Severe and potentially life-threatening allergic reactions can occur, characterized by facial swelling, shock, and anaphylaxis. Seek immediate medical help if you experience hives, rash, swelling of the lips or tongue, or breathing difficulties.

• Liver Damage: There is a risk of serious liver issues, potentially leading to liver failure. Symptoms such as abdominal bloating, jaundice, changes in stool color, or dark urine require prompt medical evaluation. The risk is heightened in those with pre-existing liver issues and individuals over 55.

• Aortic Damage: Older adults might experience severe aortic damage, such as weakening or tearing, following treatment. Immediate medical attention is needed for sudden, severe chest, back, or abdominal pain. Discuss alternative treatments if there's a history of aortic aneurysm.

• Infectious Diarrhea: The risk of Clostridioides difficile infection, causing severe diarrhea, is increased. Symptoms include rapid heart rate, foul-smelling diarrhea, fever, and frequent bowel movements. Immediate medical evaluation is necessary.

• Heart Rhythm Changes: Ciprofloxacin (Cipro) can cause QT prolongation, a potentially life-threatening heart rhythm issue. Risks are elevated in older adults, those with electrolyte imbalances, existing heart problems, or those on medications affecting heart rhythm. Emergency medical help is needed for chest pain, fainting, or shortness of breath.

• Musculoskeletal Issues in Children: Children may experience muscle, bone, or joint problems. Ciprofloxacin (Cipro) should only be used in pediatric cases when no alternatives are available.

• Sun Sensitivity: Increased skin sensitivity to sunlight can result in sunburns. Use sunscreen and protective clothing outdoors to minimize risk.

• Kidney Issues: Rarely, this medication can cause kidney problems. Staying hydrated and informing your healthcare provider of any back pain, urination difficulty, or limb swelling is crucial. Dehydration increases this risk.

Contraindications:

• Severe allergy to quinolone antibiotics.
• Concurrent use of tizanidine (Zanaflex) is advised against when taking ciprofloxacin (Cipro).

Please consult your healthcare provider for personalized advice and further information.

Common side effects:

• Nausea
• Diarrhea
• Vomiting
• Rash
• Abnormal liver blood test results

Less common but important to monitor:

• Pain or swelling in the achilles tendon or other joints and muscles
• Seizures
• Changes in thoughts or behavior
• Nerve damage symptoms (numbness, tingling, or burning sensations)
• Changes in sensitivity to touch or temperature

Serious side effects:

• Major blood vessel damage (sudden and severe chest, back, or stomach pain, shortness of breath, or pain in arms or legs)
• Infectious diarrhea (foul-smelling stools, fever, frequent bowel movements)
• Abnormal heart rhythms (chest pounding or pain, shortness of breath, feeling faint)
• Kidney problems (reduced urination, swelling in extremities)
• Liver issues (stomach bloating, yellowing of the skin or eyes, dark urine)
• Serious allergic and skin reactions (hives, blisters, skin reddening or peeling, swelling of lips or tongue, difficulty breathing)