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Important safety information regarding the use of Xhance (fluticasone) is outlined below. It is crucial to understand these warnings to prevent potential health issues. For any concerns, please consult your healthcare provider.

• Nasal Damage and Infections: Xhance (fluticasone) can cause nasal side effects such as nosebleeds, ulcers, and delayed wound healing. Yeast infections in the nasal passages, throat, esophagus, and digestive tract are possible. If you have had recent nasal trauma or surgery, inform your prescriber before using Xhance (fluticasone) as it may slow the healing process. Notify your healthcare team if you experience nosebleeds, pain, or fever.

• Eye Conditions: Use of steroid medications like Xhance (fluticasone) may increase the risk of cataracts and glaucoma. Report any vision changes to your prescriber, especially if you have a history of glaucoma, cataracts, or elevated eye pressure.

• Infection Risk: Xhance (fluticasone) can suppress the immune system, increasing infection risk, particularly in individuals with existing medical conditions or those on immunosuppressants. If you have a history of tuberculosis or any current infections, inform your prescriber. Avoid contact with individuals who have chickenpox or measles, and seek medical advice if exposed to these infections. Report symptoms like fever, cough, or chills promptly.

• Adrenal Hormone Levels: Xhance (fluticasone) can affect cortisol levels, potentially leading to Cushing's syndrome, characterized by symptoms like fat accumulation, easy bruising, weight gain, high blood pressure, and muscle weakness. These risks are elevated with high doses, prolonged use, or during stress. Inform your care team if you notice these symptoms.

• Drug Interactions: Certain medications, including ritonavir, ketoconazole, and clarithromycin, may interact with Xhance (fluticasone), causing increased levels of the medication and potential side effects. Disclose all medications you are taking to your prescriber or pharmacist before starting Xhance (fluticasone).

• Growth and Bone Development: Xhance (fluticasone) may impede growth in children and weaken bones, increasing fracture risk. It is not recommended for pediatric use. Long-term use heightens these risks, and those with additional risk factors for osteoporosis should have their bone health monitored.

When using this medication, some common side effects might occur, such as nosebleeds, which affect 5-12% of individuals, and nose ulcers, experienced by 3-8%. You might also notice nose and throat inflammation, a stuffy nose, redness inside the nose, and sinus inflammation, occurring in 2-8% of users. Headaches and sore throats are also reported by some, affecting 2-5% and 1-3% respectively. Typically mild, these effects should be discussed with a healthcare provider if they persist or worsen.

Other side effects that have been reported include a dry nose, mouth and throat pain, toothache, pressure in the ears, dizziness, stomach discomfort, and weight gain. Although these are less common, they should be monitored and brought to the attention of a healthcare provider if necessary.

Serious side effects are rare but require immediate medical attention. These include severe allergic reactions characterized by rash, breathing difficulties, or swelling of the lips, tongue, or face. In rare instances, corticosteroids administered nasally may enter the bloodstream, potentially causing unusual fatigue, weight loss, headache, swelling of the ankles or feet, increased thirst or urination, and vision problems, particularly in children or those using high doses over long periods. If these occur, seek immediate medical assistance.