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Oxycodone is a medication with a significant risk of misuse and addiction, which can result in overdose and potentially fatal consequences. It may also lead to serious, possibly life-threatening respiratory issues. To minimize these risks, your healthcare provider should prescribe the lowest effective dose for the shortest duration.

• Consider having naloxone available to counteract opioid overdose, and ensure that family or household members are informed about recognizing and responding to an opioid overdose.
• The likelihood of serious breathing problems is heightened at the start of treatment, following a dose increase, or if an incorrect dose is taken. Combining oxycodone with alcohol or other substances that cause sedation or respiratory depression can lead to severe side effects, including death.
• Be aware that other medications may interfere with how oxycodone is metabolized, altering its effectiveness or safety. It is crucial to understand proper oxycodone usage and identify drugs to avoid during treatment.
• Seek immediate medical attention if you experience symptoms such as slow or shallow breathing, significant lightheadedness, intense drowsiness or dizziness, or difficulty waking up.

• Store oxycodone securely to prevent theft, misuse, or abuse. If accidental ingestion occurs, obtain urgent medical assistance.

  For women of childbearing age, it's important to discuss the potential risks and benefits of oxycodone with your healthcare provider. Inform your doctor if you are pregnant or planning to become pregnant. This medication should only be used during pregnancy if absolutely necessary, due to a slightly increased risk of birth defects in the first trimester, and potential harm to the unborn child from prolonged use or high doses near delivery. Babies born to mothers who have used oxycodone long-term may experience severe withdrawal symptoms. Notify a healthcare professional immediately if your newborn exhibits signs such as persistent crying, slow or shallow breathing, irritability, tremors, vomiting, diarrhea, feeding difficulties, or poor weight gain.

You might experience some common side effects like nausea, vomiting, constipation, lightheadedness, dizziness, or drowsiness while taking this medication. These effects often become less bothersome as your body adjusts. If they persist or worsen, consult your healthcare provider. To manage constipation, consider increasing your dietary fiber intake, staying hydrated, and exercising regularly. A laxative might be necessary, so ask your pharmacist for advice on the best option. To minimize dizziness and lightheadedness, rise slowly from sitting or lying down.

Be aware of more serious side effects such as sleep apnea, changes in mood or mental state, severe stomach pain, difficulty urinating, or symptoms indicating adrenal gland issues like loss of appetite, unusual tiredness, or weight loss. Seek medical attention immediately if you experience any of these.

In rare cases, very serious side effects can occur, including fainting, seizures, slow or shallow breathing, or severe drowsiness and difficulty waking up. If you notice these symptoms, obtain medical assistance without delay. Additionally, although an allergic reaction to the medication is uncommon, seek emergency care if you experience rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing.

This summary does not cover all potential side effects. If you experience any other unusual symptoms, contact your healthcare provider for guidance.

Be sure to review the Warning and How to Use sections for more details. This medication may interact with certain other drugs, including some pain relievers such as Butorphanol, Nalbuphine, and pentazocine, as well as Naltrexone and samidorphan. Additionally, certain medications might alter how Oxycodone is metabolized in your body, affecting its effectiveness. Such drugs include azole antifungals like Ketoconazole, macrolide antibiotics such as Erythromycin, HIV medications like tipranavir, rifamycins including Rifabutin and Rifampin, Ritonavir, and seizure medications like Carbamazepine and Phenytoin.

Taking this medication with other substances that can cause drowsiness or breathing difficulties may increase the risk of severe side effects, such as slowed or shallow breathing and extreme drowsiness or dizziness. Inform your doctor or pharmacist if you are using other opioids for pain or cough relief, such as codeine or hydrocodone, alcohol, cannabis, sleep or anxiety medications like Alprazolam, Lorazepam, or Zolpidem, muscle relaxants such as Carisoprodol or Cyclobenzaprine, or antihistamines like Cetirizine or diphenhydramine.

Check labels on all your medications, including allergy or cough-and-cold products, as they may contain ingredients that cause drowsiness. Consult your pharmacist to ensure you use these products safely. Also, note that this medication might interfere with certain laboratory tests, such as those measuring amylase or lipase levels, potentially leading to incorrect results. Ensure all your healthcare providers, including lab personnel, are aware that you are using this medication.