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The following information outlines important safety considerations for individuals using Zetonna (ciclesonide). This medication carries certain risks and requires careful use. Please review these details and consult your healthcare provider with any concerns.

• Nosebleeds and Risk of Injury: Users may experience nosebleeds due to the thinning of nasal passage skin caused by this nasal steroid. In case of a nosebleed, sit down, lean forward, and apply pressure by pinching the soft part of your nose for 5 to 10 minutes. Seek medical attention if bleeding persists or if you feel faint. Be cautious if you have had nasal surgery, an injury, or ulcers in the nose.

• Risk of Infection: As a corticosteroid, Zetonna (ciclesonide) can suppress the immune system, increasing susceptibility to infections, including fungal infections in the nose or throat and viral infections like chickenpox. This risk is elevated with long-term use or concurrent use of other immune-weakening medications. Consult your healthcare provider if you currently have an infection.

• Altered Stress Hormone Levels: Exceeding the recommended dose or abruptly discontinuing Zetonna (ciclesonide) after prolonged use can disrupt hormone levels, potentially causing adrenal insufficiency. This risk is higher with long-term or excessive use.

• Delayed Growth in Children: Corticosteroids may impede growth in children. Regular growth monitoring by a pediatrician is advised if a child is on this medication. Discuss any concerns with your child's healthcare provider.

• Allergic Reactions: Allergic reactions may occur, potentially leading to serious conditions such as facial swelling, shock, or anaphylaxis. Seek immediate medical help if you experience hives, rash, swelling of lips or tongue, or difficulty breathing after using the medication.

• Eye and Vision Problems: Nasal corticosteroids may increase eye pressure, potentially resulting in glaucoma or cataracts, although these effects have not been reported with Zetonna (ciclesonide) specifically. If you have a history of eye conditions, consult an eye specialist before starting treatment. Report any vision changes to your healthcare provider promptly.

Please adhere to these guidelines to minimize risks and ensure safe use of Zetonna (ciclesonide).

When taking this medication, some individuals may experience common side effects such as nasal dryness or irritation, mild nosebleeds, and headaches. These are generally mild and should not cause significant concern. However, if these symptoms persist or worsen, it is advisable to consult your healthcare provider for guidance.

In rare cases, more severe side effects can occur, and these require prompt medical attention. These include severe nosebleeds, persistent pain in the nose, or a whistling sound when breathing. Additionally, signs of infection, such as a persistent sore throat, white patches in the nose or back of the throat, fever, or chills, should be reported to a healthcare professional immediately. Rarely, corticosteroids administered nasally can enter the bloodstream, potentially causing serious effects like unusual fatigue, weight loss, headaches, swelling in the ankles or feet, increased thirst or urination, and vision problems, especially in children or those using high doses over a long period.

A very serious allergic reaction to this medication is rare, but if symptoms such as rash, itching or swelling of the face, tongue, or throat, severe dizziness, or difficulty breathing occur, seek emergency medical help right away. Other serious concerns include nasal injuries, such as crusting or sores in the nose, or fungal infections in the nose or throat indicated by pain, redness, or white patches. Always consult your healthcare provider if you notice any other unusual effects.