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This medication comes with important safety considerations that you must be aware of to ensure its safe use. Below are key warnings and contraindications associated with this medication, which should be carefully reviewed. If you have any concerns, please consult with your healthcare provider.

• Heart Risks: Rarely, people might experience heart attacks or chest pain after taking zolmitriptan (Zomig), even without pre-existing heart disease. If you're at risk for heart disease and are new to triptans, your healthcare provider may assess your heart health before starting treatment. Report symptoms like chest pain, shortness of breath, or arm pain immediately, as they might indicate a heart attack. Key risk factors include a family history of heart disease, diabetes, high blood pressure, older age, smoking, and obesity.

• Irregular Heart Rhythms: Life-threatening changes in heart rhythm have been reported with triptan use. Avoid zolmitriptan if you have a history of arrhythmias. Stop the medication and inform your provider if you notice a racing heart.

• Stroke Risk: Some individuals have experienced strokes or brain bleeding with triptan use. Symptoms overlap with migraines, so accurate diagnosis is crucial before starting zolmitriptan. If you notice sudden weakness, severe headache, facial drooping, or speech changes, seek medical attention immediately.

• Blood Vessel Concerns: Zolmitriptan can cause blood vessel spasms, potentially leading to inadequate blood supply to organs, resulting in symptoms like stomach pain or Raynaud's syndrome. Rarely, it may cause vision loss. Consult your provider before taking another dose if you experience these symptoms.

• Serotonin Syndrome: While rare, increased serotonin levels can lead to serotonin syndrome, especially if taking other medications that raise serotonin. Symptoms include a racing heart, high fever, and hallucinations. Discontinue use and consult your provider if these occur.

• High Blood Pressure: Zolmitriptan may raise blood pressure, which can lead to severe complications. Monitor your blood pressure regularly and seek urgent care if you experience symptoms like headache, chest pain, or confusion.

• Specific Population Alert for PKU: The orally disintegrating tablet form of zolmitriptan contains phenylalanine, which is harmful for individuals with phenylketonuria (PKU). Ensure your healthcare provider is aware of your full medical history.

Contraindications

Do not use zolmitriptan if you have any of the following conditions, as it may lead to serious health risks:

• History of heart disease, including chest pain or heart attacks.
• Conditions causing heart blood vessel spasms or irregular heart rhythms.
• History of stroke or mini-stroke.
• Migraines accompanied by double vision, dizziness, or movement issues.
• Conditions affecting blood vessels or blood supply (e.g., peripheral artery disease).
• Uncontrolled high blood pressure.
• Recent use of another triptan or ergotamine-containing medication within 24 hours.
• Use of monoamine oxidase (MAO)-A inhibitors within the past two weeks.

Always consult with your healthcare provider before starting zolmitriptan to ensure it is safe for you.

When taking this medication, some common side effects may occur, but they are generally mild and manageable. These include feelings of nausea, dizziness, a tingling sensation in the arms or legs, and drowsiness. You might also experience dry mouth, body weakness, or a feeling of warmth or cold. Some individuals report pain, tightness, or pressure in the neck, throat, or jaw, as well as chest discomfort. An unusual taste might also be noticed.

While these effects are not usually serious, it's important to monitor your condition and inform your healthcare provider if they persist or worsen. This medication can also cause an increase in blood pressure, so regular monitoring is advised. Serious side effects, although rare, demand immediate medical attention. These include symptoms resembling a heart attack, such as severe chest pain, shortness of breath, or unusual sweating. Rapid or irregular heartbeat, fainting, and severe abdominal pain should also be addressed urgently.

Additionally, be aware of the risk of serotonin syndrome, a serious condition that may arise if this medication is combined with other drugs that increase serotonin levels. Symptoms include a rapid heartbeat, hallucinations, severe dizziness, and agitation. Lastly, though rare, severe allergic reactions can occur. Seek immediate help if you experience a rash, swelling, severe dizziness, or difficulty breathing. Always discuss any new or unusual symptoms with your healthcare provider to ensure your safety and well-being.

When using Zolmitriptan, be aware of potential interactions with other medications. It is crucial to inform your healthcare provider and pharmacist about all medications, supplements, and herbs you are currently taking.

Serious Interactions:

Avoid taking Zolmitriptan with MAO inhibitors, such as isocarboxazid, linezolid, methylene blue, phenelzine, procarbazine, rasagiline, and tranylcypromine, as it may lead to a severe and potentially fatal reaction. Most MAO inhibitors should not be used within two weeks before starting Zolmitriptan. Consult your doctor about when to begin or discontinue any medication.

Serotonin Syndrome Risk:

The risk of serotonin syndrome, a potentially dangerous condition, increases when Zolmitriptan is used with drugs that enhance serotonin levels. This includes certain antidepressants like fluoxetine, paroxetine, duloxetine, and venlafaxine, St. John's Wort, and illicit drugs such as MDMA ("ecstasy"). The risk is heightened when starting or increasing the dose of these drugs.

Interactions with Triptans and Ergotamines:

If you are taking ergotamine medications (e.g., dihydroergotamine) or other "triptan" drugs like sumatriptan or rizatriptan, it is essential to space out your doses of these medications and Zolmitriptan to minimize the chances of serious side effects. Your doctor can advise on the appropriate timing between doses.

Other Interactions:

Zolmitriptan should not be used with certain other medications without careful consideration, as it may not be recommended. These include almotriptan, bromocriptine, cisapride, and methysergide, among others. In some cases, your doctor may adjust the dosage or frequency if both medications are necessary.

For a complete list of potential interactions and guidance specific to your health situation, always consult with your healthcare provider.