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The following safety and warning information outlines crucial considerations and potential risks associated with the use of zolmitriptan (Zomig). Patients and healthcare providers should carefully review these details to ensure safe and effective use of the medication.

• Heart Concerns: Rarely, zolmitriptan (Zomig) may cause heart attacks or chest pain, even in individuals without existing heart disease. If you have a high risk for heart disease, your healthcare provider will assess your heart health before starting the medication. It may be necessary to take the first dose under medical supervision. Seek immediate medical attention if you experience symptoms such as chest pain, shortness of breath, or lightheadedness, as these could indicate a heart attack.

• Irregular Heart Rhythms: Zolmitriptan (Zomig) can lead to serious changes in heart rhythm. Individuals with conditions that cause arrhythmias should avoid this medication. If you notice a racing heart, discontinue use and consult your healthcare provider promptly.

• Stroke Risk: Some patients may experience strokes or brain injuries while using zolmitriptan (Zomig). Symptoms such as sudden weakness, severe headache, or speech difficulties require immediate medical attention. A proper migraine diagnosis before use is essential to minimize confusion with stroke symptoms.

• Blood Vessel Issues: The drug can cause blood vessel spasms, potentially leading to insufficient blood supply to parts of the body, resulting in symptoms like stomach problems or Raynaud's syndrome. Vision loss is a rare but serious risk. Consult your provider if you experience such symptoms before taking another dose.

• Serotonin Syndrome: Rarely, zolmitriptan (Zomig) may increase serotonin levels, potentially causing serotonin syndrome, especially if combined with other serotonin-raising drugs. Symptoms include a racing heart, high fever, or hallucinations. Stop the medication and seek medical advice if these occur.

• High Blood Pressure: Regularly monitor blood pressure while using zolmitriptan (Zomig), as it can increase levels. If dangerously high, symptoms like headache or chest pain may appear, requiring urgent medical care. Avoid use with uncontrolled high blood pressure.

• Phenylketonuria (PKU) Caution: The orally disintegrating tablets contain phenylalanine, which is unsafe for individuals with PKU. Inform your provider of your condition, and ensure the prescribed form is appropriate.

Contraindications: Do not use zolmitriptan (Zomig) if you have a history of heart disease, stroke, or conditions affecting blood vessels or if you have uncontrolled high blood pressure. Avoid concurrent use with other triptans or medications like MAO-A inhibitors. Always consult your healthcare provider if these conditions apply.

Common side effects:

• Nausea
• Dizziness
• Tingling or numb sensation in the arms or legs
• Feelings of sleepiness
• Dry mouth
• Weakness
• Sensations of warmth or cold
• Neck, throat, or jaw pain
• Chest tightness
• Unusual taste

Less common but important to monitor:

• Raised blood pressure

Serious side effects:

• Chest pain or pressure
• Fast or irregular heartbeat
• Fainting
• Severe stomach pain
• Bloody diarrhea
• Signs of a stroke (sudden vision changes, confusion, or weakness on one side of the body)
• Serotonin syndrome (fast heartbeat, hallucinations, severe dizziness, or unusual agitation)
• Serious allergic reactions (rash, severe dizziness, or difficulty breathing)

Interactions with high risk of serious adverse effects and should be avoided:

• MAO inhibitors (isocarboxazid, Linezolid, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, Tranylcypromine)
• Ergotamine medications (such as Dihydroergotamine)
• Other triptan drugs (such as Sumatriptan, Rizatriptan)
• Almotriptan
• Bromocriptine
• Cisapride
• Eletriptan
• Ergoloid Mesylates
• Ergonovine
• Ergotamine
• Frovatriptan
• Levomethadyl
• Mesoridazine
• Methylergonovine
• Methysergide
• Naratriptan
• Terfenadine
• Thioridazine

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Drugs that increase serotonin (MDMA, St. John's wort, SSRIs such as Fluoxetine/paroxetine, SNRIs such as Duloxetine/[Venlafaxine](https://savehealth.com/venlafaxine))
• Acecainide
• Ajmaline
• Alfentanil
• Amiodarone
• Amitriptyline
• Amoxapine
• Amphetamine
• Aprindine
• Azimilide
• Benzhydrocodone
• Benzphetamine
• Bretylium
• Chloroquine
• Citalopram
• Codeine
• Desipramine
• Desvenlafaxine
• Dextroamphetamine
• Dibenzepin
• Dihydrocodeine
• Disopyramide
• Dofetilide
• Dolasetron
• Doxepin
• Dronedarone
• Droperidol
• Erythromycin
• Escitalopram
• Fenfluramine
• Fentanyl
• Flecainide
• Fluconazole
• Fluvoxamine
• Foscarnet
• Gemifloxacin
• Granisetron
• Halofantrine
• Hydrocodone
• Hydromorphone
• Hydroquinidine
• Ibutilide
• Imipramine
• Isradipine
• Lasmiditan
• Levomilnacipran
• Levorphanol
• Lidoflazine
• Lisdexamfetamine
• Lithium
• Lorcainide
• Lorcaserin
• Mefloquine
• Meperidine
• Methadone
• Methamphetamine
• Milnacipran
• Mirtazapine
• Morphine
• MorphineSulfate Liposome
• Nefazodone
• Nortriptyline
• Octreotide
• Ondansetron
• Oxycodone
• Oxymorphone
• Palonosetron
• Paroxetine
• Pentamidine
• Pirmenol
• Pixantrone
• Prajmaline
• Probucol
• Procainamide
• Prochlorperazine
• Propafenone
• Protriptyline
• Quinidine
• Reboxetine
• Remifentanil
• Sematilide
• Sertraline
• Sibutramine
• Sotalol
• Spiramycin
• St John's Wort
• Sufentanil
• Tapentadol
• Tedisamil
• Tramadol
• Trazodone
• Trifluoperazine
• Trimipramine
• Venlafaxine
• Vilazodone
• Vortioxetine
• Ziprasidone

Interactions with low risk that usually do not require a change in therapy:

• Cimetidine