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When taking this medication, you might experience mild side effects like nausea, vomiting, heartburn, headache, dizziness, difficulty sleeping, changes in appetite, increased sweating, acne, or discomfort at the injection site. These are generally manageable, but if they persist or worsen, it’s important to consult your healthcare provider.

For more serious concerns, this medication can affect blood sugar levels, potentially leading to or worsening diabetes. Watch for signs such as increased thirst or urination and speak with your healthcare provider if these occur. If you have diabetes, it’s important to monitor your blood sugar levels regularly.

This medication can also lower your immune system’s ability to fight infections, increasing your risk of serious infections. If you notice persistent sore throat, fever, chills, cough, or white patches in the mouth, contact your healthcare provider immediately.

Additionally, report any serious side effects such as unusual weight gain, changes in menstrual periods, bone or joint pain, easy bruising or bleeding, mood changes, muscle weakness, swelling, slow wound healing, skin changes, vision problems, irregular heartbeat, or symptoms of stomach bleeding. Seek urgent medical attention if you experience seizures or symptoms of a severe allergic reaction, like rash, swelling, or breathing difficulties.

This summary does not cover all possible side effects. If you notice other unusual effects, reach out to your healthcare provider for advice.

Certain medications and products can interact with this drug. These include aldesleukin, desmopressin, and mifepristone. Additionally, drugs that may increase the risk of bleeding or bruising, such as antiplatelet medications like clopidogrel, blood thinners like warfarin and dabigatran, as well as NSAIDs like ibuprofen, celecoxib, aspirin, and salicylates, might interact. If your doctor has prescribed low-dose aspirin (typically 81-162 milligrams daily) to help prevent a heart attack or stroke, continue taking it unless advised otherwise by your doctor. For more information, consult your doctor or pharmacist.

Other drugs can influence how your body processes methylprednisolone, potentially impacting its effectiveness. Such drugs include azole antifungals (like ketoconazole), cyclosporine, estrogens, HIV protease inhibitors (such as darunavir), macrolide antibiotics (like erythromycin), ritonavir, St. John's wort, and certain seizure medications (such as phenytoin and phenobarbital).

This medication may also affect the results of certain laboratory tests, such as skin tests, by causing false results. Ensure that all your healthcare providers and laboratory personnel are aware that you are taking this medication.