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It is crucial to be aware of important safety information concerning the use of Advil Cold and Sinus (ibuprofen / pseudoephedrine). Please review the following warnings and precautions carefully and consult your healthcare provider with any questions or concerns.

• Stomach Bleeding Risk: Advil Cold and Sinus contains ibuprofen, which may increase the risk of developing stomach ulcers and bleeding. Immediate medical attention is required if you experience symptoms such as dizziness, black or bloody stools, or persistent stomach pain. Increased risk factors include being an older adult, having a history of stomach bleeding, taking aspirin, NSAIDs, corticosteroids, or blood thinners, consuming three or more alcoholic drinks daily, and prolonged use of this medication.

• Heart Attack and Stroke Risk: Ibuprofen in Advil Cold and Sinus can elevate the risk of blood clots, potentially leading to heart attack or stroke. Use the lowest effective dose for the shortest time. Individuals with heart problems should seek medical advice before using this medication. Avoid use if you have recently undergone or plan to have heart surgery. Seek emergency help if you experience chest pain, difficulty breathing, sudden weakness on one side, or difficulty speaking or walking.

• Worsening of Medical Conditions: Do not use Advil Cold and Sinus if you have any pre-existing conditions unless cleared by your healthcare provider, as it may exacerbate these issues. Inform your provider of any medical history, especially regarding serious side effects from pain relievers, stomach, liver, kidney, heart, respiratory, thyroid, diabetes, glaucoma, or urinary conditions.

• Severe Allergic Reactions: There is a risk of serious allergic reactions, including anaphylaxis, which can be life-threatening. Inform your provider if you are allergic to aspirin or NSAIDs. If symptoms like hives, rashes, facial swelling, or trouble breathing occur, seek immediate medical attention.

• Potential Harm to Unborn Baby: Pregnant individuals should discuss risks and benefits with their healthcare provider before using this medication. Pseudoephedrine may be associated with birth defects if taken during the first trimester, while ibuprofen can harm the unborn baby or cause delivery complications if used in the latter half of pregnancy.

Contraindications: Do not use Advil Cold and Sinus if you have a known allergy to NSAIDs, are about to undergo or have recently had heart surgery, or if you are taking a monoamine oxidase inhibitor (MAOI) within two weeks of using this medication.

Always consult with your healthcare provider to ensure this medication is safe for you, especially if you have underlying health conditions or are taking other medications.

Common side effects:

• Nervousness
• Difficulty sleeping
• Stomach upset
• Heartburn
• Nausea
• Skin rashes

Less common but important to monitor:

• Weakness
• Ringing in the ears (tinnitus)
• Vomiting

Serious side effects:

• Signs of a heart attack (chest pain or tightness, pain radiating to the shoulder, arm, neck, or jaw)
• Stroke symptoms (weakness in one part of your body or face, slurred speech, sudden headache, or confusion)
• Stomach bleeding (feeling faint, vomiting blood, bloody or dark stools, severe stomach pain)
• Allergic reactions (hives, rash, blisters, swelling of the lips or tongue, difficulty breathing, skin reddening)

When taking Advil Cold & Sinus, it's important to be aware of potential interactions with other substances:

Alcohol: Consuming alcohol while using this medication can increase the risk of stomach bleeding. Signs of stomach bleeding include bloody or black stools and vomiting blood or material that resembles coffee grounds. It's advisable to avoid alcohol during treatment.

Caffeine: Both pseudoephedrine (a component of Advil Cold & Sinus) and caffeine can raise blood pressure and heart rate. Combining them may intensify these effects. If you have a history of high blood pressure or heart disease, consult your healthcare provider before consuming caffeine while on this medication.

Other Medications: Avoid taking Advil Cold & Sinus with other products containing Ibuprofen, pseudoephedrine, phenylephrine, or chlorpheniramine to prevent excessive intake of these ingredients. Additionally, do not use this medication if you are currently taking or have recently stopped taking a monoamine oxidase inhibitor (MAOI), as this combination can lead to dangerous changes in blood pressure. Always consult your healthcare provider before starting any new medications or supplements while using Advil Cold & Sinus.

Being mindful of these interactions can help ensure the safe and effective use of Advil Cold & Sinus.