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Oxycodone carries a risk of misuse and dependency, potentially leading to overdose and even death. It may also cause serious, and possibly life-threatening, respiratory issues. To minimize these risks, it is essential that your doctor prescribes the lowest effective dose for the shortest duration.

• Discuss with your healthcare provider whether naloxone is appropriate for you to have on hand as a precaution against opioid overdose. Educate your family or household members on recognizing opioid overdose signs and administering treatment.
• The likelihood of severe breathing problems increases at the initiation of treatment, following a dose increment, or if a wrong dose/strength is taken. Combining this medication with alcohol or other substances that induce drowsiness or respiratory issues can lead to severe consequences, including death.
• Be aware that other medications may interfere with the elimination of oxycodone, thus impacting its effectiveness. Ensure you understand the correct way to take oxycodone and know which other drugs to avoid.
• Seek immediate medical attention if you experience symptoms such as slow or shallow breathing, unusual lightheadedness, significant drowsiness or dizziness, or difficulty awakening.
• Do not break, crush, chew, or dissolve this medication, as doing so with extended-release oxycodone can result in a fatal overdose.
• Store this medication securely to prevent theft, misuse, or abuse. In case of accidental ingestion by someone else, seek medical assistance without delay.

For women of childbearing age, it is important to discuss the risks and benefits with your doctor before using this medication. If you are pregnant or planning to become pregnant, inform your healthcare provider. Oxycodone should only be used during pregnancy when absolutely necessary, as it might slightly increase the risk of birth defects if taken during the first two months. Prolonged or high-dose use near delivery can harm the unborn baby. Opt for the lowest effective dose for the shortest period to mitigate risks. Newborns of mothers who have used this drug long-term may experience severe (possibly fatal) withdrawal symptoms. Notify the doctor immediately if your newborn exhibits symptoms such as incessant crying, slow or shallow breathing, irritability, shaking, vomiting, diarrhea, poor feeding, or difficulty gaining weight.

When taking this medication, you might experience common side effects such as nausea, vomiting, constipation, dry mouth, weakness, sweating, lightheadedness, dizziness, or drowsiness. These usually improve over time. For constipation, incorporate dietary fiber, stay hydrated, and engage in regular physical activity; a pharmacist can recommend a suitable laxative if needed. To minimize dizziness and lightheadedness, rise slowly from sitting or lying down. Occasionally, you might see an empty tablet shell in your stool, which is harmless, as the medication has already been absorbed.

While many people do not encounter serious side effects, it's crucial to be aware of them. Contact your healthcare provider immediately if you experience sleep apnea, mental or mood changes like agitation, confusion, or hallucinations, severe stomach or abdominal pain, difficulty urinating, or signs of adrenal gland issues such as loss of appetite, unusual tiredness, or weight loss. Seek urgent medical attention if you have very serious side effects, including fainting, seizures, slow or shallow breathing, or severe drowsiness with difficulty waking up.

Though a severe allergic reaction is rare, if you notice symptoms like a rash, itching or swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing, obtain medical help promptly. This is not a comprehensive list of side effects, so consult your healthcare provider if you notice any other unusual symptoms.

Certain medications can interact with this drug. These include pain relievers like Butorphanol, Nalbuphine, and pentazocine, as well as Naltrexone and samidorphan. Taking these along with your medication might increase the chance of serious side effects, such as slowed or shallow breathing, and severe drowsiness or dizziness. Inform your doctor or pharmacist if you're using other products that can make you sleepy or affect breathing, such as opioid pain relievers (like codeine, hydrocodone), alcohol, marijuana (cannabis), sleep or anxiety medications (like Alprazolam, Lorazepam, Zolpidem), muscle relaxants (like Carisoprodol, Cyclobenzaprine), or antihistamines (like Cetirizine, diphenhydramine).

It's important to check the labels of all your medications, including allergy or cold products, as they might have ingredients that cause drowsiness. Consult your pharmacist about how to use these products safely.

Some drugs can change how your body processes oxycodone, affecting its effectiveness. These include antifungals (like Ketoconazole), antibiotics (like Erythromycin), Mifepristone, HIV treatments (such as tipranavir), rifamycins (like Rifabutin, Rifampin), Ritonavir, and certain seizure medications (like Carbamazepine, Phenytoin).

Additionally, this drug may interfere with certain lab tests, such as those measuring amylase or lipase levels, potentially leading to false results. Be sure to inform lab staff and all your healthcare providers that you are taking this medication.