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The use of oxycodone/acetaminophen (also known as Percocet) carries significant safety warnings due to potential risks and side effects. Below is a summary of these critical safety considerations:

• Risk of Addiction and Misuse: This medication is a controlled substance that can lead to addiction and misuse. Only take it as prescribed. Adjusting the dose or frequency without consulting your healthcare provider can increase the risk of life-threatening side effects, including dangerously slow breathing and overdose.

• Respiratory Depression: Oxycodone/acetaminophen can cause severe breathing problems, especially when starting treatment or increasing the dose. Avoid combining it with alcohol or other medications that depress the nervous system. Carry naloxone, a medication that can reverse respiratory depression, if prescribed, and seek immediate medical help for breathing difficulties.

• Opioid Overdose: Overdose symptoms include extremely slow breathing, unresponsiveness, and cold or clammy skin. Ensure you and those around you recognize these signs and have access to naloxone. If an overdose is suspected, use naloxone and call emergency services immediately.

• Liver Damage: Exceeding the recommended daily dose of acetaminophen can lead to serious liver damage. Adults should not exceed 4 grams per day. Those with liver issues, or who consume alcohol regularly, should use a lower dose.

• Drug Interactions: This medication can interact with various other drugs, potentially increasing side effects. Inform your healthcare provider of all medications you are taking to avoid harmful interactions.

• Pregnancy and Newborn Risk: Using oxycodone/acetaminophen during pregnancy can lead to neonatal opioid withdrawal syndrome in newborns, which is potentially life-threatening. Pregnant individuals should discuss risks with their healthcare provider and use the lowest effective dose for the shortest duration if necessary.

• Allergic Reactions: Severe allergic reactions can occur, such as anaphylaxis or serious skin reactions. Discontinue use and seek immediate medical attention if signs of an allergic reaction appear.

• Withdrawal Symptoms: Long-term use can lead to physical dependence, with withdrawal symptoms occurring if the medication is abruptly stopped. Consult with your doctor before making any changes to your medication regimen.

• Low Blood Pressure and Adrenal Insufficiency: This medication may cause low blood pressure or low adrenal hormone levels, leading to dizziness or fatigue. Notify your healthcare provider if you experience these symptoms.

• Seizures: Individuals with a history of seizures may have an increased risk when taking oxycodone/acetaminophen. Seek medical assistance immediately if a seizure occurs.

Contraindications: Do not use this medication if you have severely slowed breathing, severe asthma, stomach blockage, or known allergies to oxycodone or acetaminophen.

Always store this medication securely to prevent misuse, and consult your healthcare provider if you have any questions or concerns regarding its use.

When taking this medication, you may encounter some common side effects such as nausea, vomiting, dizziness, sleepiness, constipation, and itching. These effects are generally mild and may subside as your body adjusts to the medication. To manage constipation, consider incorporating dietary fiber, staying hydrated, and engaging in regular physical activity. If you feel dizzy or lightheaded, try rising slowly from sitting or lying positions to minimize discomfort.

Less common side effects include headache, sweating, heartburn, bloating, muscle pain, changes in taste, stomach pain, and fluctuations in blood pressure or heartbeat. While these are generally not severe, it is important to monitor their persistence and consult your healthcare provider if they become bothersome.

There are rare but serious side effects that require immediate medical attention. These include dangerously slow breathing, symptoms of an overdose such as extreme sleepiness and slow heartbeat, and signs of opioid withdrawal like anxiety and irritability. Additionally, watch for serious allergic reactions, including skin rash, hives, blistering, or peeling skin, as well as shortness of breath and a rapid heartbeat. If you experience any of these severe symptoms, seek urgent medical care. Always remain vigilant to any unexpected effects and discuss them with your healthcare provider for guidance.

When taking Percocet (oxycodone/acetaminophen), be aware of potential interactions with other medications or substances. It is crucial to inform your doctor and pharmacist about all medications and supplements you are using, whether they are prescribed, over-the-counter, or herbal.

Certain medications should not be combined with Percocet. These include nalmefene, naltrexone, and safinamide. Your doctor may choose an alternative treatment if you're using these.

Other medications, such as abiraterone acetate, alprazolam, and buprenorphine, might not be recommended for use with Percocet unless necessary. If both are prescribed together, your doctor might adjust dosages or frequency of use.

Moreover, taking Percocet with medications like carbamazepine, fosphenytoin, or warfarin may elevate the risk of side effects. However, in some cases, using these combinations might be required, and your doctor will manage dosages accordingly.

Additionally, be cautious when using other substances that can cause drowsiness or breathing issues, such as alcohol, marijuana, sleep aids, or muscle relaxants. These can heighten the risk of severe side effects, including slowed or shallow breathing and extreme drowsiness.

Percocet can also interact with medications affecting its removal from the body, such as azole antifungals, macrolide antibiotics, certain HIV drugs, and seizure medications. These interactions can influence how Percocet works.

Lastly, Percocet might interfere with specific lab tests, potentially causing incorrect results. Ensure your healthcare providers are informed that you are taking this medication. Always consult with your healthcare team before making any changes to your medication regimen.