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It is important to be aware of the risks and precautions associated with taking nonsteroidal anti-inflammatory drugs (NSAIDs), such as naproxen. Here are some key safety considerations:

• Heart Risks: Naproxen may occasionally increase the likelihood of a heart attack or stroke. This risk can arise at any time during usage but is more pronounced with prolonged use. Those at higher risk include older adults and individuals with existing heart disease or risk factors like smoking, family history of heart disease, high blood pressure, or diabetes. Avoid taking naproxen immediately before or after heart bypass surgery.

• Gastrointestinal Risks: There is a rare chance of experiencing severe bleeding in the stomach or intestines, which can occur suddenly without warning. This risk is particularly higher in older adults.

• Immediate Medical Attention: Discontinue use and seek medical help promptly if you experience any of the following rare but serious symptoms: persistent stomach or abdominal pain, black or tarry stools, vomit resembling coffee grounds, chest, jaw, or left arm pain, shortness of breath, unusual sweating, confusion, weakness on one side of the body, difficulty speaking, or sudden changes in vision.

• Consultation: Discuss with your healthcare provider or pharmacist to thoroughly understand the potential benefits and risks of using naproxen.

By following these guidelines, you can better manage your health while using this medication.

You might experience mild side effects such as an upset stomach, nausea, heartburn, headache, drowsiness, or dizziness. These are usually not serious, but if they persist or worsen, it's important to consult your healthcare provider. It's also possible for this medication to increase your blood pressure, so regular monitoring is advised.

Be vigilant for more serious side effects and contact your healthcare provider immediately if you experience easy bruising or bleeding, difficulty or pain when swallowing, changes in hearing like ringing in the ears, mood or mental changes, signs of kidney issues such as a change in urine output, vision changes, or symptoms of heart failure including swelling of the ankles or feet, unusual tiredness, or unexpected weight gain.

In rare cases, this medication can cause severe liver damage, which requires urgent medical attention. Watch for symptoms like persistent nausea or vomiting, loss of appetite, dark urine, stomach or abdominal pain, and yellowing of the skin or eyes. A severe allergic reaction is also rare but serious. Seek immediate medical help if you have symptoms such as fever, swollen lymph nodes, rash, itching or swelling (especially of the face, tongue, or throat), severe dizziness, or difficulty breathing.

This summary doesn't cover all possible side effects. If you observe any other unusual symptoms, reach out to your healthcare provider for advice.

Certain medications can interact with this drug, including Aliskiren, ACE inhibitors like Captopril and Lisinopril, angiotensin II receptor blockers such as Valsartan and Losartan, Cidofovir, corticosteroids like Prednisone, Lithium, and diuretics such as Furosemide. Avoid taking this medication alongside antacids or drugs that reduce stomach acid, including Famotidine, ranitidine, and proton pump inhibitors like Omeprazole, as they can alter the drug's protective coating, leading to rapid release and increased side effects.

This medication may also heighten the risk of bleeding when used with other drugs that cause bleeding, such as anti-platelet medications like Clopidogrel and blood thinners like Dabigatran, Enoxaparin, or Warfarin. Be vigilant with all prescription and over-the-counter medications, as many contain pain relievers or fever reducers like Aspirin and NSAIDs such as Celecoxib, Ibuprofen, or Ketorolac, which are similar to naproxen and may increase side effects. However, if your doctor advises you to take low-dose aspirin (81-162 milligrams daily) for heart attack or stroke prevention, continue doing so unless instructed otherwise, as daily naproxen use can reduce aspirin's effectiveness. Discuss the potential risks and benefits with your doctor and inquire about alternative pain or fever treatments.

This medication may affect certain laboratory tests, potentially leading to inaccurate results. Ensure that all laboratory staff and your doctors are aware of your medication use.