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Naproxen, a type of nonsteroidal anti-inflammatory drug (NSAID), carries certain risks and requires careful consideration before use. Below are key safety warnings and precautions:

• Cardiovascular Risks: There is a potential, though rare, increase in the risk of heart attack or stroke associated with naproxen, which may occur at any time during treatment but is more likely with prolonged use. This risk is heightened in older adults or those with existing heart conditions or risk factors such as smoking, a family history of heart disease, high blood pressure, or diabetes. It is crucial not to use this medication immediately before or after coronary artery bypass graft (CABG) surgery.

• Gastrointestinal Risks: Naproxen can infrequently lead to severe, and sometimes fatal, bleeding in the stomach or intestines. This risk can arise unexpectedly and is more prevalent in older individuals.

• Serious Side Effects: Discontinue naproxen immediately and seek emergency medical attention if you experience any of the following symptoms: persistent stomach or abdominal pain, black or tarry stools, vomit resembling coffee grounds, pain in the chest, jaw, or left arm, shortness of breath, excessive sweating, confusion, unilateral weakness, difficulty speaking, or sudden changes in vision.

• Consultation and Risk Assessment: Discuss with your healthcare provider or pharmacist to fully understand the benefits and potential risks of taking naproxen, ensuring it aligns with your health needs and conditions.

Taking this medication may lead to some mild side effects, such as an upset stomach, nausea, heartburn, headache, drowsiness, or dizziness. These are generally not serious, but if they persist or worsen, it is advisable to consult a healthcare professional. Additionally, this medication can potentially increase blood pressure, so regular monitoring is recommended. If elevated readings occur, inform your healthcare provider.

There are some serious side effects to be aware of, though they are less common. Contact a healthcare provider immediately if you experience easy bruising or bleeding, difficulty or pain when swallowing, changes in hearing like ringing in the ears, mood or mental changes, or signs of kidney issues such as altered urine output. Vision changes and symptoms of heart failure, including swelling of the ankles or feet, unusual fatigue, or sudden weight gain, are also serious and warrant prompt medical attention.

In rare instances, this drug may cause serious liver damage. Seek immediate medical help if you experience persistent nausea or vomiting, loss of appetite, dark urine, stomach or abdominal pain, or yellowing of the eyes or skin. An allergic reaction to this medication is also rare but serious, and requires urgent medical care if symptoms such as fever, swollen lymph nodes, rash, itching or swelling (particularly of the face, tongue, or throat), severe dizziness, or difficulty breathing occur. This is not an exhaustive list of side effects; consult a healthcare provider if you notice any other unexpected symptoms.

Certain medications can interact with this drug, so it's important to be aware of them. These include Aliskiren, ACE inhibitors like Captopril and Lisinopril, angiotensin II receptor blockers such as Valsartan and Losartan, Cidofovir, corticosteroids like Prednisone, Lithium, and diuretics like Furosemide. Avoid taking this medication alongside antacids or drugs that reduce stomach acid, such as Famotidine, ranitidine, or proton pump inhibitors like Omeprazole, as they can affect the drug's coating and cause it to release too quickly, leading to increased side effects.

There is also an increased risk of bleeding when this medication is taken with other drugs that promote bleeding, such as anti-platelet medications like Clopidogrel or anticoagulants like Dabigatran, Enoxaparin, and Warfarin. Additionally, many over-the-counter and prescription medications contain pain relievers or fever reducers like Aspirin and NSAIDs (e.g., Celecoxib, Ibuprofen, Ketorolac), which are similar to Naproxen and can heighten side effects if taken together.

If you're on low-dose aspirin (81-162 mg per day) to prevent heart attack or stroke, continue taking it unless advised otherwise by your doctor, as daily use of naproxen might reduce aspirin's effectiveness in preventing these conditions. Discuss with your healthcare provider to understand the risks and benefits and to explore alternative medications for pain and fever management.

Lastly, inform all your healthcare providers and lab technicians about your use of this medication, as it may interfere with certain lab tests and lead to inaccurate results.