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AirDuo (fluticasone/salmeterol) is a medication used for certain respiratory conditions. However, there are important safety considerations and warnings associated with its use. It is crucial to understand these aspects to ensure safe and effective treatment. If you have any concerns, please consult your healthcare provider.

• Asthma Attacks: Do not use AirDuo for immediate relief during an asthma attack or if you are experiencing worsening breathing difficulties, as it is not intended for rapid action. Use a rescue inhaler, like albuterol, for immediate symptom relief.

• Fungal Infections: The steroid component in AirDuo can lead to a fungal infection in the mouth and throat known as thrush. To minimize this risk, rinse your mouth with water and spit after each use. If you develop symptoms such as white patches, a cotton-like feeling, or pain in your mouth, contact your healthcare provider promptly.

• Bronchospasm Risk: In some cases, inhaled medications like AirDuo can cause muscle spasms in the lungs, leading to breathing difficulties. If you experience such symptoms, use your rescue inhaler immediately and seek medical attention.

• Infection Susceptibility: AirDuo may weaken your immune system, increasing your susceptibility to infections like upper respiratory infections and pneumonia. Inform your provider if you are being treated for serious infections, such as tuberculosis.

• Hormonal Effects: Adhere to your prescribed dosage of AirDuo. Overuse can result in increased absorption of steroids, potentially affecting stress hormone levels, blood sugar, and blood pressure.

• Growth Concerns in Children: Inhaled steroids may affect growth in children. Therefore, healthcare providers will prescribe the lowest effective dose and monitor growth regularly.

• Eye Health: Long-term use of inhaled steroids has been linked to eye problems such as glaucoma and cataracts. If you have a history of these conditions, consult your eye care provider and report any vision changes.

• Cardiovascular Effects: Salmeterol, a component of AirDuo, can affect heart rate and blood pressure. Regular monitoring may be needed if you have pre-existing heart conditions. Report symptoms like dizziness or a rapid heartbeat to your healthcare provider.

• Potassium Levels: There is a risk of low blood potassium levels, particularly with overuse of AirDuo. Symptoms may include fatigue, muscle cramps, or a tingling sensation. Inform your provider if these occur.

• Allergic Reactions: Be aware of potential allergic reactions, which can be severe. Seek immediate medical attention if you experience symptoms such as hives, swelling, or difficulty breathing.

Contraindications:

• Do not use AirDuo for treating sudden or severe asthma attacks.
• Avoid if you have known allergies to fluticasone, salmeterol, lactose, or milk proteins.

Always follow your healthcare provider's instructions and discuss any concerns or unusual symptoms you experience while using AirDuo.

Common side effects:

• Runny nose
• Sore throat
• Headaches

Less common but important to monitor:

• Coughing
• Back pain
• Oral thrush

Serious side effects:

• Serious allergic reactions
• Sudden narrowing of the airways
• Heart-related issues

When using AirDuo RespiClick 232/14, it's important to be aware of potential interactions with other medications and health conditions. Here are some key considerations:

Drug Interactions:

• Strong CYP3A4 Inhibitors: Medications like Ritonavir and Ketoconazole can increase the levels of fluticasone propionate in your body, potentially leading to more pronounced side effects.

• Monoamine Oxidase Inhibitors (MAOIs) and Tricyclic Antidepressants: These can enhance the effects of salmeterol on your cardiovascular system, which may increase the risk of heart-related side effects.

• Beta-Blockers: Using beta-blockers with AirDuo RespiClick can reduce the effectiveness of salmeterol and may lead to severe bronchospasm, a sudden constriction of the airways.

• Diuretics: Certain diuretics, especially non-potassium-sparing ones, can lower potassium levels. When combined with salmeterol, this effect might be intensified, leading to hypokalemia (low potassium levels).

Disease Interactions:

• Cardiovascular Conditions: If you have heart-related issues, using AirDuo RespiClick may require caution due to potential cardiovascular effects.

• Diabetes: This medication can affect blood sugar levels, so monitoring is advisable for individuals with diabetes.

• Seizure Disorders: There may be an increased risk of seizures when using this medication.

• Liver Impairment: Liver conditions can influence how the body processes this medication, potentially leading to increased side effects.

• Infections: AirDuo RespiClick can suppress the immune system, making it important to monitor for infections.

• Osteoporosis: Long-term use may decrease bone mineral density, increasing the risk of osteoporosis.

• Ocular Conditions: There is a potential risk for glaucoma and cataracts with this medication.

Food and Alcohol Interactions:

No specific food or alcohol interactions have been identified with AirDuo RespiClick. However, it's always best to consult with your healthcare provider regarding your diet and alcohol consumption while on this medication.

Therapeutic Duplication:

Using multiple medications from the same class, such as corticosteroids, can increase the risk of side effects. For instance, combining AirDuo RespiClick with another corticosteroid like Triamcinolone is generally not recommended unless specifically advised by your healthcare provider.

Always inform your healthcare provider about all the medications you're taking, including over-the-counter drugs and supplements, to ensure safe and effective use of AirDuo RespiClick.