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The following safety information highlights potential risks and important precautions associated with the use of this medication. Please read carefully and consult your healthcare provider if you have any questions or concerns.

• Hormone-Related Issues and Withdrawal: Long-term use of topical hydrocortisone over large areas can lead to adrenal suppression, where the body reduces its own steroid hormone production. Abrupt discontinuation may result in withdrawal symptoms such as swelling, rash, and burning sensations. To avoid this, your healthcare provider will prescribe the lowest effective dose for the shortest duration. If extended use is necessary, monitoring of adrenal function through laboratory tests may be required. Do not stop using the medication suddenly without medical advice. Risks include prolonged use, excessive application, covering treated areas with bandages, and use in young children.

• Elevated Blood Sugar Levels: Extended use of topical hydrocortisone on large body areas can increase blood sugar levels, potentially leading to diabetes. If you have diabetes, regular monitoring of blood sugar levels is recommended to ensure safety. Report any increased thirst or frequent urination to your provider. Risks are associated with prolonged and excessive use.

• Increased Risk of Infections: Long-term use can elevate the risk of skin or oral infections. Avoid using hydrocortisone on infected skin, as it may worsen the condition. Contact your provider if you notice redness, swelling, pain, pus, or if symptoms do not improve after a week. These may indicate a new infection. Risks arise from using the medication for more than seven days.

• Skin Reactions: Extended use beyond medical guidance can lead to various skin issues, including thinning, stretch marks, spider veins, burning, itching, irritation, dryness, inflamed hair follicles, color changes, or rash. Your provider will recommend the lowest effective dose to minimize these risks. Report any new or worsening skin problems to your healthcare provider promptly. Risks include excessive and inappropriate use.

Please ensure adherence to these guidelines for safe and effective use of topical hydrocortisone. Always consult your healthcare provider before making any changes to your medication regimen.

When using this medication, some common side effects may occur, including stinging, burning, itching, skin irritation, dryness, and inflamed hair follicles. These effects are usually mild, but if they persist or worsen, it is advisable to consult your healthcare provider for further guidance.

In some cases, additional side effects might be noticed, such as acne, unusual hair growth, small red bumps known as folliculitis, changes in skin color, or the appearance of stretch marks. Skin thinning, discoloration, and pruning or wrinkling of the skin can also occur. While many people do not experience serious side effects, monitoring is essential.

A rare but severe side effect is bleeding from the treated area, especially if the medication is used for anal itching. If this occurs, seek medical attention immediately. Though very uncommon, allergic reactions such as rash, severe dizziness, swelling (particularly of the face, tongue, or throat), and difficulty breathing require immediate medical help. Always stay vigilant and contact your healthcare provider if you notice any concerning symptoms.