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Amphotericin B is primarily used to treat serious fungal infections. It is often reserved for severe infections due to its potential side effects and is effective against a broad range of fungi.

When taking amphotericin B, it is important to monitor kidney function, as the drug can be nephrotoxic. Regular blood tests should be conducted to check serum creatinine and blood urea nitrogen (BUN) levels. Additionally, monitoring electrolytes, particularly potassium and magnesium, is crucial since amphotericin B can cause imbalances. Liver function tests and complete blood counts should also be monitored to detect any potential adverse effects. It is advisable to watch for signs of infusion-related reactions, such as fever, chills, and hypotension.

The major side effect of amphotericin B is nephrotoxicity, which refers to kidney damage. It can lead to decreased kidney function and electrolyte imbalances, particularly affecting potassium and magnesium levels. Regular monitoring of kidney function and electrolytes is recommended during treatment with amphotericin B.

Amphotericin B is administered intravenously because it is poorly absorbed from the gastrointestinal tract. This method ensures that the medication reaches the bloodstream directly, allowing it to effectively treat systemic fungal infections.

The nurse should closely monitor the client's renal function, as amphotericin B can be nephrotoxic. This includes regular checks of serum creatinine and blood urea nitrogen (BUN) levels. Additionally, monitoring for signs of electrolyte imbalances, particularly hypokalemia and hypomagnesemia, is important. The nurse should also observe for infusion-related reactions, such as fever, chills, and hypotension.