Amphotericin B

Drug Details

Amphotericin B is a potent antifungal medication used to treat serious fungal infections such as aspergillosis, cryptococcosis, and systemic candidiasis. It works by binding to ergosterol, a key component of fungal cell membranes, forming pores that lead to cell death. While effective, amphotericin B can cause side effects, including fever, chills, nausea, and kidney issues. To reduce these risks, lipid-based formulations like liposomal amphotericin B have been developed, offering similar efficacy with fewer adverse effects. Despite the availability of newer antifungal agents, amphotericin B remains a critical option for treating severe fungal infections.