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This medication, danazol, comes with significant safety warnings and precautions that must be observed to ensure safe use. Please carefully review the following key points and discuss any concerns with your healthcare provider:

• Pregnancy Warning: Danazol should not be used by women who are pregnant or planning to become pregnant, as it can cause harm to an unborn child. Women of childbearing age should begin taking this medication during their menstrual period or after confirming a negative pregnancy test. It is crucial to use reliable non-hormonal birth control methods, such as condoms or a diaphragm with spermicide, while on this medication. If you suspect you are pregnant, contact your doctor immediately.

• Blood Clot Risks: There is a rare but serious risk of blood clots, including strokes, associated with danazol. Do not use this medication if you have a predisposition to blood clots. Immediate medical attention is required if you experience symptoms such as severe headache, weakness on one side of the body, difficulty speaking, vision changes, chest pain, or swelling and pain in the limbs.

• Liver Disease Risk: Long-term use of danazol increases the risk of developing liver disease, which can result in significant liver damage. Be vigilant for signs of liver issues, including persistent fatigue, nausea, vomiting, dark urine, or jaundice (yellowing of the skin or eyes), and contact your healthcare provider if these occur.

• Increased Intracranial Pressure: Some individuals may experience increased pressure in the brain, leading to severe headaches, nausea, vomiting, or vision changes. This condition can result in permanent vision loss and occasionally death. Seek urgent medical care if these symptoms appear.

These precautions are crucial for your safety while using danazol. Always consult with your healthcare provider for personalized advice and to discuss any potential risks specific to your health condition.

Common side effects:

• weight gain
• acne
• sweating
• flushing
• changes in voice like hoarseness or a change in pitch
• abnormal hair growth in women
• vaginal dryness or irritation
• decrease in breast size

Less common but important to monitor:

• swelling of the hands, ankles, or feet
• menstrual changes such as spotting or missed periods
• mood alterations like nervousness or mood swings
• liver problems

Serious side effects:

• sudden liver issues
• severe clotting leading to strokes
• severe allergic reactions including rash, itching, swelling of the face, tongue, or throat, severe dizziness, or trouble breathing

Interactions with high risk of serious adverse effects and should be avoided:

• Simvastatin

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Anisindione
• Atorvastatin
• Bupropion
• Dicumarol
• Fluvastatin
• Lovastatin
• Pexidartinib
• Phenprocoumon

Interactions with low risk that usually do not require a change in therapy:

• Carbamazepine
• Cyclosporine
• Tacrolimus
• Warfarin