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This medication is not suitable for use during pregnancy due to potential harm to an unborn child. Women of childbearing age should initiate this medication during their menstrual cycle. If starting at another time, a negative pregnancy test is required prior to beginning treatment. It is crucial to avoid pregnancy while taking this medication. Discuss with your healthcare provider about employing reliable non-hormonal contraceptive methods, such as condoms or a diaphragm with spermicide, during treatment. Should you suspect pregnancy or confirm you are pregnant, contact your healthcare provider immediately.

Danazol has, on rare occasions, been associated with very serious and potentially fatal conditions such as blood clots (e.g., stroke), liver disease, and increased intracranial pressure (benign intracranial hypertension). Seek immediate medical attention if you experience symptoms including persistent nausea or vomiting, a severe or unrelenting headache, unilateral body weakness, difficulty speaking, visual disturbances, intense abdominal pain, darkened urine, jaundice (yellowing of the eyes or skin), or mental/mood changes like confusion.

Some individuals taking this medication may experience mild side effects such as weight gain, acne, flushing, sweating, changes in voice (hoarseness or pitch alteration), increased body hair in women, vaginal dryness or irritation, and reduced breast size. These effects are generally manageable, but if they persist or worsen, it is advisable to inform a healthcare professional.

While most people do not encounter serious issues, it's important to be aware of potential severe side effects. Contact a healthcare provider immediately if you notice swelling in the hands, ankles, or feet, changes in menstrual cycles (such as spotting or missed periods), or any mental and mood changes like nervousness or mood swings.

Allergic reactions to this medication are extremely rare but can be serious. Seek urgent medical attention if you experience symptoms such as a rash, itching, swelling (particularly of the face, tongue, or throat), severe dizziness, or difficulty breathing. Always stay vigilant for any other unusual effects and consult a healthcare provider if needed.