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This safety information outlines important risks and precautions associated with the use of testosterone gel. Please review these details thoroughly and consult your healthcare provider if you have any questions or concerns.

• Transfer Risk: Testosterone gel can transfer to others through skin contact with the application site, potentially causing early puberty in children and male characteristics in females. Avoid contact with unwashed or unclothed application sites.

• Blood and Clotting Risks: The gel can increase red blood cell count, potentially leading to blood clots. Regular blood tests may be necessary to monitor this risk.

• Cardiovascular Risks: Testosterone gel may increase the risk of heart attack, stroke, or sudden cardiac death. Seek emergency help if you experience chest pain, cold sweats, pain in the left arm, difficulty breathing, trouble walking or speaking, or weakness on one side of the body.

• Misuse and Dependency: As a controlled substance, testosterone gel carries a risk of misuse, dependency, and addiction. Misuse can cause serious heart and mental health issues, including heart attack, heart failure, stroke, liver issues, depression, delusions, hallucinations, and aggression. This risk increases with higher doses or concurrent use with other testosterone-containing medications.

• Prostate Issues: The gel can exacerbate symptoms in individuals with an enlarged prostate. Inform your provider of any changes in urination patterns.

• Liver Concerns: While testosterone gel is not known to cause liver damage, be vigilant for symptoms such as stomach pain, pale stools, dark urine, or yellowing of the skin or eyes.

• Fluid Retention: The gel may cause swelling in the arms and legs due to fluid retention, particularly if you are taking corticosteroids or have heart, liver, or kidney conditions. Contact your provider if swelling occurs.

• Sleep Apnea: Testosterone gel may worsen sleep apnea, especially if you have a history of obesity or lung disease. Report increased daytime sleepiness or observed breathing interruptions during sleep.

• High Calcium Levels: The gel can cause elevated calcium levels, particularly in individuals with cancer, leading to symptoms like muscle weakness, frequent urination, thirst, stomach pain, and blood in urine. Regular blood tests may be needed to monitor calcium levels.

Contraindications:

• Men with breast or prostate cancer.
• Women who are pregnant or breastfeeding.

If any of these conditions apply to you, consult your healthcare provider before using testosterone gel.

Common side effects:

• Skin irritation
• Skin rash
• Itchiness
• Acne
• High red blood cell count
• Enlarged prostate

Less common but important to monitor:

• Headaches
• Enlargement of male breasts
• Trouble sleeping
• Abnormal dreams
• Urinary tract infections
• Increased urination frequency
• Muscle weakness
• Hair loss
• Lower sex drive
• Mood changes
• Appetite fluctuations
• Depression
• Nervousness
• Anxiety
• Dizziness
• Nausea
• Sweating
• Changes in smell or taste

Serious side effects:

• Heart attack symptoms (chest pain and difficulty breathing)
• Stroke symptoms (face drooping and weakness on one side)
• Blood clots (leg pain or lung complications)
• Withdrawal symptoms (depression and fatigue)
• Liver damage (stomach pain, jaundice, and dark urine)

Testosterone therapy can interact with various medications, potentially altering their effects or increasing the risk of side effects. It's important to be aware of these interactions to manage your health effectively.

Blood Thinners (Anticoagulants): Testosterone may enhance the effects of blood-thinning medications like Warfarin, increasing the risk of bleeding. Regular monitoring of blood clotting parameters is recommended when using these medications together.

Diabetes Medications: Testosterone can lower blood sugar levels, which may amplify the effects of insulin and oral diabetes drugs, leading to hypoglycemia (low blood sugar). If you're on diabetes medications, your doctor might need to adjust your dosage and monitor your blood sugar levels more closely.

Corticosteroids: Combining testosterone with corticosteroids such as Prednisone can increase the risk of fluid retention and swelling (edema), especially in individuals with heart, liver, or kidney conditions. Close monitoring is advised when these medications are used together.

Cyclosporine: Testosterone may raise cyclosporine levels in the blood, potentially leading to kidney toxicity. If you're taking cyclosporine, your doctor should monitor your blood levels to prevent adverse effects.

Medications Affecting Testosterone Levels: Certain drugs can influence how your body processes testosterone. For example, medications like Phenobarbital and Phenytoin may decrease testosterone levels, while others like Fluoxetine and Itraconazole can increase them. These changes might affect the effectiveness of your testosterone therapy.

Prostate Health: Testosterone can stimulate prostate tissue growth, potentially worsening conditions like benign prostatic hyperplasia (BPH) or accelerating the progression of prostate cancer. Regular prostate monitoring is essential during testosterone therapy.

Sleep Apnea: Testosterone may worsen or trigger obstructive sleep apnea by affecting respiratory drive and muscle tone. If you have sleep apnea or are at risk, discuss this with your doctor before starting testosterone therapy.

Heart, Liver, or Kidney Disease: Testosterone-induced fluid retention can exacerbate conditions such as heart failure, liver impairment, or kidney dysfunction. Inform your healthcare provider about any existing health issues to ensure safe use of testosterone.

Always inform your healthcare provider about all medications, supplements, and health conditions before starting testosterone therapy. This ensures that potential interactions are identified and managed appropriately, safeguarding your health.