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Before starting this medication, you must first get tested to be sure you are HIV negative. Your doctor will order lab tests before starting this medication and during treatment to make sure you do not have HIV infection. Using this product will not always prevent HIV infection. To get the most benefit, use this medication exactly as directed and follow all prevention actions (see also Uses section). Some HIV tests can miss HIV infection in a person who has recently become infected. Tell your doctor right away if you have any signs of HIV infection such as a sore throat that doesn't go away, tiredness, fever, night sweats, rash, diarrhea, joint/muscle aches, enlarged lymph nodes. If you become HIV positive, you will need to take other medications to treat HIV. If you have HIV and receive only this medication, your HIV may become harder to treat.

Injection site pain/discomfort, swelling, redness, itching, bruising, or a hardened mass or lump may occur. Diarrhea, headache, dizziness, tiredness, and trouble sleeping may also occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: signs of liver problems (such as nausea/vomiting that doesn't stop, loss of appetite, stomach/abdominal pain, yellowing eyes/skin, dark urine), mental/mood changes (such as depression, thoughts of suicide). A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Do not use this medication with other products that contain cabotegravir. Other medications can affect the removal of cabotegravir from your body, which may affect how this product works. Examples include rifamycins (such as rifampin, rifapentine), certain drugs used to treat seizures (such as carbamazepine, oxcarbazepine, phenobarbital, phenytoin, primidone), among others.