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Rifampin

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generic Rifampin+syrspend Sf

Rifampin, also known by its brand name Rifadin, is an antibiotic primarily used to treat both active and latent tuberculosis (TB). In addition, it helps prevent the spread of meningococcal infections in individuals who carry the bacteria without showing symptoms. Belonging to the rifamycin class of antibiotics, Rifampin works by inhibiting an essential enzyme that bacteria require to produce proteins, thereby halting their growth and spread. This medication is effective only against bacterial infections and will not work for viral infections like the common cold or flu. It is important to use antibiotics only when necessary to avoid resistance. Rifampin is usually taken orally once or twice daily, and when used for TB, it may be prescribed alongside other medications such as isoniazid. A notable side effect is a temporary change in the color of teeth, body fluids, and urine. Always consult with your healthcare provider before taking Rifampin to ensure it is appropriate for your condition.
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Rifampin WarningsRifampin Side EffectsRifampin InteractionsFAQs

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150MG, Rifampin (30 Capsules)

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$25.26

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Rifampin dosage forms

The average cost for 30 Capsules of Rifampin (generic Rifampin+syrspend Sf) at 150MG is $23.29 with a free coupon. This is 23.96% off the average retail price of $97.2
DosageQuantityPrice fromPer unit
150MG30 Capsules$23.29$0.78
300MG30 Capsules$23.3$0.78

Rifampin Warnings

This document contains essential safety warnings and contraindications for the use of Rifampin (Rifadin). Review this information carefully and consult your healthcare provider if you have any questions or concerns.

  • Liver Health Risks: Rifampin can lead to severe liver damage. Regular blood tests are necessary to monitor liver function, especially with long-term use. Avoid alcohol and other liver-harming substances. Discuss any history of liver issues with your provider, as Rifampin may exacerbate these conditions. Seek immediate medical attention if you experience symptoms such as loss of appetite, nausea, vomiting, dark urine, or yellowing of the skin or eyes.

  • Meningococcal Infection Limitation: Rifampin is not intended for treating active meningococcal infections. It is prescribed for carriers of meningococcal bacteria without symptoms, typically for a short duration of about two days, to prevent antibiotic resistance.

  • Allergic Reactions: Be aware of potential allergic reactions, which can range from rashes and swelling to severe skin reactions and flu-like symptoms. If you experience any unusual symptoms, contact your healthcare provider promptly. Consistent daily use is crucial, especially in tuberculosis treatment, to avoid kidney complications.

  • Bleeding Risks: Rifampin can increase bleeding tendencies, particularly in those with low vitamin K levels. Regular blood tests may be necessary, and vitamin K supplements might be prescribed. Report any unusual bleeding or bruising to your healthcare provider immediately.

  • Diabetes Management: Rifampin can complicate blood sugar control in individuals with diabetes. Discuss your diabetes management plan with your healthcare provider before starting the medication.

  • Dosage and Side Effects: For tuberculosis, it's advisable to take Rifampin once daily, not exceeding 600 mg per day. If daily adherence is challenging, an alternative dosing schedule may be suggested, but be aware of increased side effects such as flu-like symptoms and potential organ injury.

  • Hormonal and Vitamin D Effects: Rifampin accelerates the breakdown of certain hormones and vitamin D, possibly leading to imbalances in calcium and phosphate levels and increased parathyroid hormone.

Contraindications: Do not use Rifampin if you are taking saquinavir with ritonavir, or any of the medications atazanavir, darunavir, fosamprenavir, saquinavir, or tipranavir. Additionally, avoid Rifampin if it is within four weeks of starting praziquantel.

If you encounter any of these situations or have further inquiries, promptly consult with your healthcare provider.

Rifampin Side Effects

Common side effects:

  • upset stomach
  • heartburn
  • nausea
  • headache
  • temporary color change in urine, sweat, saliva, or tears

Less common but important to monitor:

  • diarrhea
  • fever
  • nervous system issues affecting energy, movement, or behavior
  • nerve pain
  • changes in vision
  • menstrual cycle irregularities
  • fluid retention in the face, arms, or legs
  • oral thrush
  • new yeast infection

Serious side effects:

  • signs of kidney problems
  • mental or mood changes
  • unusual tiredness
  • easy bruising or bleeding
  • small red spots on the skin
  • new or worsening shortness of breath
  • chest pain
  • signs of severe liver disease
  • severe intestinal condition related to C. difficile bacteria
  • very serious allergic reaction

Rifampin Interactions

Interactions with high risk of serious adverse effects and should be avoided:

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

Interactions with low risk that usually do not require a change in therapy:

Rifampin FAQs
What is the drug rifampin used for?

Rifampin is primarily used to treat tuberculosis and to eliminate Neisseria meningitidis from the nasopharynx in asymptomatic carriers. It is also used in combination with other antibiotics to treat certain bacterial infections, such as those caused by Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus (MRSA). Additionally, rifampin is sometimes used in the treatment of leprosy and to prevent Haemophilus influenzae type b infections.

Yes, rifampin is considered a strong antibiotic. It is commonly used to treat serious bacterial infections, including tuberculosis and certain types of bacterial meningitis. It works by inhibiting the synthesis of bacterial RNA, which is essential for bacterial growth and replication.

While taking rifampin, one should avoid consuming alcohol, as it can increase the risk of liver damage. Additionally, rifampin can interact with many medications, so it is important to inform the healthcare provider of all medications being taken, including over-the-counter drugs and supplements. Rifampin can also reduce the effectiveness of hormonal birth control, so alternative contraceptive methods should be considered. Foods that may affect the absorption of rifampin, such as high-fat meals, should be discussed with a healthcare provider. Lastly, it is advisable to avoid wearing contact lenses, as rifampin can cause discoloration of bodily fluids, which may stain them.

Rifampicin is primarily used to treat bacterial infections, including tuberculosis and certain types of bacterial infections such as leprosy. It is also used in combination with other antibiotics to treat infections caused by Mycobacterium avium complex and to prevent meningococcal meningitis in people who have been exposed to Neisseria meningitidis.

Rifampin is not typically classified as a high-risk medication, but it does require careful monitoring due to potential side effects and drug interactions. It is important for patients to follow their healthcare provider's instructions and report any unusual symptoms. Regular liver function tests may be recommended, as rifampin can affect liver enzymes.

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