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This document outlines essential safety and warning information for the use of Descovy (emtricitabine / tenofovir alafenamide). It is crucial to understand the potential risks and precautions associated with this medication. Please carefully review the following points and consult your healthcare provider if you have any concerns or questions.

• Hepatitis B and HIV Coinfection: If you have both hepatitis B and HIV, discontinuing Descovy can lead to a severe worsening of your liver condition. Do not stop taking this medication without consulting your healthcare provider, as they will need to monitor your liver function for several months after stopping.

• HIV Prevention (PrEP): Descovy is used as pre-exposure prophylaxis (PrEP) to help prevent HIV infection in individuals who are HIV-negative. Prior to initiating PrEP, and then every three months during treatment, an HIV test is required. If you contract HIV while on Descovy for PrEP, your treatment plan will need to be adjusted, as Descovy alone is insufficient to treat HIV.

• Kidney Concerns: Descovy may lead to kidney issues. It is advised to avoid medications that could further harm the kidneys, such as high doses of NSAIDs. Your healthcare provider will conduct tests before and during treatment to monitor kidney health. Report any persistent bone, muscle pain, or weakness to your provider immediately.

• Immune System Changes: The medication can cause an immune reconstitution syndrome, where the immune system becomes overly active. This can lead to the immune system attacking normal cells. Watch for new symptoms like fever, hair loss, or bulging eyes, and report them to your healthcare provider promptly.

• Liver and Lactic Acid Issues: There are rare cases of liver problems, including fatty liver disease, and lactic acidosis, a buildup of lactic acid in the blood, both of which are potentially life-threatening.

• Drug Interactions: Descovy's efficacy can be reduced by certain drugs for HIV, seizures, bacterial infections, or herbal supplements, which may lead to the spread of HIV. Always inform your healthcare provider and pharmacist about any other medications or supplements you are taking.

• Contraindications for PrEP: Descovy should not be used for PrEP in individuals who are already HIV-positive or unsure of their HIV status.

By adhering to these guidelines and maintaining open communication with your healthcare provider, you can help ensure safe and effective use of Descovy.

When taking this medication, you might experience some mild side effects such as diarrhea, nausea, headaches, trouble sleeping, back pain, or a change in skin color on the palms or soles. These effects are common and usually not serious, but if they persist or worsen, it's important to consult your healthcare provider for advice.

Some other side effects that might occur include feeling tired, belly pain, or changes in mood such as depression or anxiety. While these are generally manageable, you should still discuss them with your healthcare provider if they become a concern.

There are also some rare but serious side effects that require immediate medical attention. These include symptoms of lactic acidosis, such as extreme tiredness, muscle pain, belly pain, and breathing difficulties. Kidney problems might present as tiredness, confusion, nausea, decreased urination, and swelling in the legs. Additionally, liver issues could manifest as persistent nausea, vomiting, lack of appetite, pain in the right side of the stomach, yellowing of the eyes or skin, and changes in urine and stool color.

In very rare cases, there could be a severe allergic reaction characterized by a rash, itching or swelling, particularly of the face, tongue, or throat, severe dizziness, or trouble breathing. If you experience any of these serious symptoms, seek medical help immediately. Always stay in touch with your healthcare provider regarding any side effects you experience while on this medication.