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Tafenoquine may remain in your body for an extended period, which means side effects might appear later or persist longer than anticipated. Common side effects like trouble sleeping, anxiety, or nightmares can occur, but they are usually mild and manageable. If these persist beyond three days or worsen, it's important to consult a healthcare professional.

While many individuals experience no severe side effects, you should be vigilant for any serious symptoms. Contact a healthcare provider immediately if you notice eye or vision problems. Seek urgent medical attention if you experience severe side effects such as mental or mood changes, including hallucinations or confusion, unusual tiredness, rapid breathing, pale skin, shortness of breath, a fast heartbeat, dizziness, a persistent or severe headache, yellowing of the eyes or skin, or dark urine.

Although rare, a serious allergic reaction to tafenoquine can occur. Immediate medical attention is necessary if you encounter symptoms like a rash, itching or swelling especially on the face, tongue, or throat, severe dizziness, or trouble breathing. This summary does not cover all possible side effects. If you experience any unusual symptoms, reach out to a healthcare professional for guidance.