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This medication carries several important safety warnings that you should be aware of before use. It is crucial to discuss any concerns with your healthcare provider.

• Blood Cell Changes: Pyrimethamine (Daraprim) may affect your red and white blood cells, as well as platelets. Watch for symptoms like fatigue, weakness, pale skin, irregular heartbeats, shortness of breath, or dizziness, which can indicate anemia. Also, if you are prone to infections or bruise easily, inform your healthcare provider. Your doctor might adjust your dosage and will routinely monitor your blood cell counts.

• Folic Acid Deficiency: This medication can reduce folic acid levels, potentially leading to anemia. Those with liver or kidney issues, conditions that result in low folic acid, or those taking phenytoin (Dilantin) are at a higher risk. Be vigilant for signs of anemia as previously mentioned and notify your provider if they occur.

• Risk of Seizures: At doses of 300 mg or higher, pyrimethamine (Daraprim) can provoke seizures, particularly if you have a history of seizures. Your healthcare provider may start you on a lower dose to minimize this risk. Always inform them of any past seizure activity.

• Severe Allergic Reactions: Discontinue use immediately and contact your healthcare provider if you experience symptoms such as a sore throat, skin rashes, extreme itching, or swelling of the tongue, lips, or neck, as these may signal a serious allergic reaction.

Please ensure you follow your healthcare provider’s instructions and report any adverse effects or symptoms promptly.

When taking this medication, some individuals may experience common side effects such as nausea, vomiting, and a loss of appetite. These effects are usually mild, but if they persist or worsen, it's important to consult your healthcare provider.

In some cases, more serious side effects can occur, particularly at higher doses. These include issues with blood such as anemia, which may cause symptoms like severe tiredness, pale lips or skin, and a rapid heartbeat. There is also a risk of easy bruising or bleeding, frequent infections indicated by a persistent sore throat or high fever, and swelling or pain of the tongue. If you notice any of these, contact your healthcare provider promptly. Regular blood tests and the use of folic or folinic acid can help mitigate these risks.

Very serious side effects, though rare, require immediate medical attention. These include blood in the urine, chest pain, and irregular heartbeats, whether slow or fast. An allergic reaction to the medication is also rare but serious. Symptoms may include a rash, severe dizziness, swelling of the face, tongue, or throat, and difficulty breathing. If any of these occur, seek urgent medical care.

This is not an exhaustive list of potential side effects. If you notice any other unusual symptoms, it is advisable to reach out to your healthcare provider for further guidance.