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Yes, mefloquine is still prescribed, primarily for the prevention and treatment of malaria. However, its use may be limited due to potential side effects, and healthcare providers often consider individual patient factors and alternative medications when prescribing it.

Mefloquine can cause several toxic effects, primarily affecting the central nervous system. These effects may include dizziness, headache, insomnia, vivid dreams, anxiety, depression, and in some cases, more severe neuropsychiatric symptoms such as hallucinations, psychosis, or seizures. It is important for individuals taking mefloquine to be monitored for these symptoms, and they should contact a healthcare provider if they experience any concerning side effects.

The choice of malaria medication with the least side effects depends on several factors, including the specific type of malaria, the region where it was contracted, and the patient's medical history. Generally, artemisinin-based combination therapies (ACTs) are considered effective and well-tolerated for treating uncomplicated malaria. Among these, artemether-lumefantrine is commonly used and has a favorable side effect profile. However, it is important for individuals to consult with a healthcare provider to determine the most appropriate medication based on their specific circumstances.

Mefloquine toxicity refers to the adverse effects that can occur when someone takes mefloquine, an antimalarial medication, at high doses or for prolonged periods. Symptoms of mefloquine toxicity can include neuropsychiatric effects such as anxiety, depression, hallucinations, and confusion. Other possible symptoms include dizziness, balance problems, and gastrointestinal disturbances. It is important for individuals experiencing these symptoms to seek medical attention promptly.

As of the latest information, tafenoquine is a newer drug approved for malaria prophylaxis. It is used for both the prevention and treatment of malaria and is particularly noted for its long half-life, which allows for less frequent dosing compared to other antimalarial medications. However, it is important for individuals to consult with a healthcare provider to determine the most appropriate prophylactic treatment based on their specific travel plans and health conditions.