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The following safety information outlines important considerations and precautions when using Coartem (artemether / lumefantrine). It is crucial to review these details and discuss any concerns with your healthcare provider.

• Heart-related Issues: Individuals with heart rhythm disorders, electrolyte imbalances, or those on specific medications such as certain antibiotics, antidepressants, and antipsychotics should avoid using Coartem. It is particularly important if you have a family history of QT prolongation or are currently using medications that also cause QT prolongation. Additionally, conditions like low potassium (hypokalemia) and low magnesium (hypomagnesemia) can increase risks. Ensure your healthcare provider is informed about any heart-related conditions or medications you are taking.

• Concurrent Use with Other Antimalarials: Inform your healthcare provider if you have recently taken other antimalarial drugs. Combining Coartem with other antimalarials may pose serious heart risks.

• Malaria Recurrence: To enhance the absorption of Coartem and reduce the likelihood of malaria returning, it is essential to take this medication with food, despite any decrease in appetite.

Please consult your healthcare provider for any additional guidance or if you have questions regarding the use of Coartem.

When taking this medication, some common side effects may include headache, dizziness, loss of appetite, and reduced energy levels. Joint and muscle pain are also frequently reported, but these effects are usually mild. If they persist or worsen, consult with your healthcare provider for guidance.

Other side effects that may occur include fever, chills, fatigue, nausea, vomiting, abdominal discomfort, and difficulties with sleep. If you experience these effects, especially if they are severe, it's important to reach out to your healthcare provider.

In rare cases, more serious side effects may develop, such as chest pain, severe dizziness, fainting, or a rapid and irregular heartbeat. If you experience any of these, seek immediate medical attention. Additionally, a very serious allergic reaction, although uncommon, may occur. Symptoms can include rash, itching or swelling, particularly of the face, tongue, or throat, severe dizziness, or difficulty breathing. Urgent medical care is necessary should these symptoms arise.

While this list covers many potential side effects, it's not exhaustive. If you notice other unusual effects, it is advisable to contact your healthcare provider for further advice.

When you are treated with Coartem (artemether/lumefantrine), it's crucial to inform your doctor about all medications you have taken for malaria in the four weeks before, during, and after this treatment. Certain antimalarial drugs, like halofantrine, should not be used within a month of Coartem, as severe, potentially fatal interactions can occur.

Many other medications, aside from Coartem, can impact heart rhythm by causing QT prolongation. These include other antimalarials such as quinine and quinidine, heart rhythm medications like Amiodarone and Sotalol, certain antipsychotics such as Pimozide, and some antibiotics like Erythromycin and Ciprofloxacin.

Additionally, some drugs can influence how Coartem is processed in your body, potentially altering its effectiveness. Such drugs include azole antifungals (e.g., Ketoconazole), HIV medications like Efavirenz, rifamycins such as Rifampin, and herbal supplements like St. John's wort.

Conversely, Coartem might affect the removal of other medications from your system, impacting their effectiveness. These can include antidepressants like Amitriptyline, heart medications such as metoprolol, and others.

Importantly, Coartem may reduce the effectiveness of hormonal birth control methods (pills, patches, rings), increasing the risk of pregnancy. Discuss with your healthcare provider about using additional reliable contraceptive methods. Report any unusual spotting or breakthrough bleeding, as these could indicate reduced birth control effectiveness. Always keep your doctor informed about all medications, including over-the-counter drugs and supplements, to manage any potential interactions safely.