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This document outlines essential safety information regarding the use of aztreonam (Azactam). It is important to understand the potential risks and precautions involved. Always consult your healthcare provider if you have any concerns.

• Allergic Reactions: Individuals with allergies to beta-lactam antibiotics, such as penicillins, cephalosporins, and carbapenems, should exercise caution. Although aztreonam (Azactam) is generally considered safe for those with severe penicillin allergies, there remains a slight risk of an allergic response. Symptoms may include facial swelling, anaphylaxis, and, in rare cases, toxic epidermal necrolysis (TEN), a serious skin reaction. If you exhibit symptoms such as hives, rash, red skin, lip or tongue swelling, or difficulty breathing, seek immediate medical assistance.

• Infectious Diarrhea: Aztreonam (Azactam), like other antibiotics, may increase the likelihood of a Clostridioides difficile (C. diff) infection. This can lead to severe diarrhea, which can be life-threatening. C. diff infection symptoms include a rapid heart rate, foul-smelling diarrhea, fever, nausea, frequent bowel movements (up to 15 times per day), or bloody stools. If you experience these symptoms, seek medical attention promptly for testing and treatment.

• Hard-to-Treat Infections: It is crucial that aztreonam (Azactam) is used for the right type of infection and duration as prescribed by your healthcare provider. Misuse, such as taking it for the wrong illness or incorrect duration, can lead to drug-resistant bacteria, increasing the risk of severe infections that are difficult to treat.

For any signs of overdose or unusual reactions, contact medical services immediately. Always adhere to your healthcare provider's instructions when using this medication.

When taking this medication, you may experience some common side effects such as diarrhea, nausea, vomiting, dizziness, headache, blurred vision, or mild redness and discomfort at the injection site. These are generally mild and often do not cause concern, but if they persist or worsen, it's advisable to speak with a healthcare provider. Some individuals may also notice swelling or pain in the vein after an IV injection or discomfort at the IM injection site, which are usually not serious.

However, some side effects can be more serious and require prompt medical attention. These include a fast or irregular heartbeat, confusion, easy bruising or bleeding, ringing in the ears, seizures, chest pain, and signs of liver issues like persistent nausea, vomiting, abdominal pain, yellowing of the eyes or skin, and dark urine. Additionally, signs of ongoing infection such as fever and sore throat should be reported to a doctor.

In rare cases, the medication may cause a severe intestinal condition due to C. difficile bacteria, presenting as diarrhea that doesn't stop, abdominal pain, or blood in the stool. Avoid using anti-diarrhea or opioid products, as they could worsen these symptoms. Prolonged use might also lead to oral thrush, vaginal yeast infections, or new bacterial infections, so watch for white patches in the mouth or changes in vaginal discharge.

A very serious allergic reaction is rare but requires immediate medical attention if you experience a rash, hives, blisters, swelling of the face, lips, or tongue, or have difficulty breathing. Always contact your healthcare provider if you notice any side effects or symptoms not listed here.

Aztreonam, also known as Azactam, can interact with certain medications and supplements. It is important to inform your doctor and pharmacist about all the medications, including over-the-counter drugs, vitamins, and dietary or herbal supplements, that you are currently taking.

Key interactions to be aware of include cefoxitin and imipenem. These interactions may affect how your medications work or increase the risk of side effects. Furthermore, Aztreonam may interfere with certain laboratory tests, such as some diabetic urine tests, potentially leading to inaccurate results. Ensure that all healthcare professionals and lab personnel are aware of your Aztreonam use to prevent any misinterpretation of test results.

Additionally, using Aztreonam with the Cholera Vaccine, Live is typically not recommended unless necessary. If prescribed together, your healthcare provider may need to adjust the dosage or frequency of one or both treatments. Always follow your healthcare provider's instructions carefully.