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This medication requires careful consideration due to potential risks and safety concerns. It is essential to understand these warnings and discuss any questions with your healthcare provider.

• Allergic Reactions: If you have a known allergy to beta-lactam antibiotics such as penicillins, cephalosporins, or carbapenems, aztreonam (Azactam) is generally considered safe. However, there is a rare possibility of an allergic reaction to aztreonam itself. Symptoms may include facial swelling, shock, anaphylaxis, and in rare cases, a severe skin reaction called toxic epidermal necrolysis (TEN). If you experience hives, rash, swelling of the lips or tongue, or difficulty breathing, seek immediate medical attention.

• Infectious Diarrhea: The use of antibiotics like aztreonam can increase the risk of infection with Clostridioides difficile (C. diff), leading to potentially life-threatening diarrhea. This condition is different from common antibiotic-related diarrhea and includes symptoms such as a rapid heart rate, foul-smelling or bloody diarrhea, fever, nausea, and frequent bowel movements. If you notice these symptoms, it is crucial to seek medical help promptly for testing and treatment.

• Hard-to-Treat Infections: It is important for your healthcare provider to monitor your use of aztreonam to ensure it is used for the correct type and duration of treatment. Inappropriate use, whether too short or too long, can contribute to the development of drug-resistant bacteria, increasing the risk of severe infections that are challenging to manage.

Currently, no specific contraindications are noted for this medication. Always consult with your healthcare provider for personal advice and guidance.

Common side effects:

• diarrhea
• nausea
• vomiting
• dizziness
• headache
• swelling and discomfort at the injection site

Less common but important to monitor:

• oral thrush
• new yeast infections

Serious side effects:

• fast or irregular heartbeat
• confusion
• easy bruising or bleeding
• ringing in the ears
• seizures
• chest pain
• signs of liver issues (persistent nausea, abdominal pain, yellowing of the skin or eyes, dark urine)
• symptoms of a continuing infection (fever or sore throat)
• severe intestinal condition caused by C. difficile (persistent diarrhea, abdominal pain, blood in stools)
• very serious allergic reaction (rash, itching, swelling of the face, tongue, or throat, severe dizziness, trouble breathing)

Interactions with high risk of serious adverse effects and should be avoided:

• Cholera Vaccine, Live

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• cefoxitin
• imipenem