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This medication is associated with certain risks and requires careful consideration before use. Below are essential safety guidelines and warnings to help ensure safe and effective use. Always consult your healthcare provider with any concerns or questions.

• Reduced Blood Flow Risks: This medication can significantly reduce blood flow to the brain, hands, and feet, potentially leading to a stroke or tissue damage. The risk increases when taken with certain other medications, such as azole antifungals, macrolide antibiotics, HIV protease inhibitors, and some antidepressants. Inform your healthcare provider of all medications you are taking to prevent harmful interactions.

• Heart Attack Risks: Dihydroergotamine can constrict blood vessels in the heart, increasing the risk of heart attack or irregular heartbeats. Avoid use if you have heart disease or risk factors such as high blood pressure, high cholesterol, smoking, obesity, diabetes, or a family history of heart problems. Always follow up with your healthcare provider to monitor heart health, and seek urgent medical attention if you experience chest pain or tightness.

• Stroke Warning: This medication may increase the risk of stroke or brain damage. Use only for migraine symptoms as directed. Immediate medical attention is necessary if you notice symptoms like sudden dizziness, confusion, or weakness on one side of the body.

• High Blood Pressure Caution: Dihydroergotamine can elevate blood pressure, even if you have no prior history of hypertension. Do not use if you have uncontrolled high blood pressure.

• Rebound Headaches: Overuse of migraine medications, including dihydroergotamine, can cause rebound headaches. Limit use to less than 10 days per month unless advised otherwise by your healthcare provider.

• Pregnancy Warning: Avoid use during pregnancy due to risks of preterm labor and harm to the unborn baby, including low birth weight and bone issues. Consult your healthcare provider if you are pregnant or planning to become pregnant.

• Fibrosis Risk: In rare cases, long-term use has been linked to fibrosis in the stomach, lungs, or heart. Use only as necessary and discuss preventive options with your healthcare provider if frequent use is needed.

• Nasal Spray Irritation: Nasal sprays containing this medication may cause irritation such as stuffy or runny nose, taste changes, or pain. These effects typically resolve in a few hours, but consult your provider if they persist or are bothersome.

Contraindications: Do not use this medication if you have any of the following conditions or factors, as it may pose serious health risks:

• Concurrent use of macrolide antibiotics, protease inhibitors, or other medications that constrict blood vessels.
• Use of other ergot medications or triptans within 24 hours.
• Heart conditions, chest pain, or history of heart attack.
• Uncontrolled high blood pressure.
• Hemiplegic or basilar migraines.
• Peripheral arterial disease.
• Sepsis.
• Recent blood vessel surgery.
• Severe liver or kidney problems.
• Pregnancy or breastfeeding.

In case of overdose, seek immediate medical attention. Always follow your healthcare provider's instructions and report any unusual symptoms or side effects promptly.

Dihydroergotamine may lead to mild side effects like a sore or runny nose, sore throat, changes in taste, dizziness, or nausea. These are common and usually temporary, but if they persist or worsen, it is advisable to consult your healthcare professional. While many individuals do not experience severe side effects, it is important to be aware of them. This medication can occasionally cause a significant reduction in blood flow. Discontinue use and seek medical attention if you experience serious symptoms such as an unusually slow or fast heartbeat, weakness in your legs, muscle pain, tingling or numbness, cold sensations in your extremities, or severe pain in the stomach area.

In rare instances, dihydroergotamine may lead to very serious side effects that require immediate medical intervention. These include pain in the jaw or left arm, chest pain or pressure, sudden fatigue, weakness on one side of the body, difficulty speaking, changes in vision, and mental confusion. Additionally, though very rare, severe allergic reactions can occur. Be vigilant for signs such as a rash, itching, swelling particularly around the face, tongue, or throat, severe dizziness, or trouble breathing, and seek emergency help if they occur.

Always be mindful that other side effects may occur, and if you experience any other unusual symptoms, it is important to contact your healthcare provider for advice. This information is intended to help you recognize potential side effects and seek timely assistance if needed.

Dihydroergotamine may interact with several medications, potentially impacting your treatment. It is important to inform your healthcare provider about all the medications and supplements you are taking, including prescription, over-the-counter drugs, vitamins, and herbal products.

Certain drugs should not be used with Dihydroergotamine, as they may cause serious interactions. These include medications like Almotriptan, Clarithromycin, and Epinephrine, among others. In these cases, your doctor might suggest alternative treatments or alter your current medications.

Other medications, such as Abametapir and Bromocriptine, are generally not recommended to be used with Dihydroergotamine but may be necessary in some situations. If both are required, your doctor will adjust the dosage or how often you take them.

Additionally, combining Dihydroergotamine with drugs like Nitroglycerin or Propranolol might increase the risk of side effects. Nevertheless, using them together might be essential for your condition, and your healthcare provider will carefully manage your treatment plan to minimize any potential risks.

Lastly, be cautious with products like bronchodilators, decongestants, or stimulants, as they can elevate your heart rate or blood pressure. Always discuss with your pharmacist how to safely use these products, especially if they are part of cough-and-cold remedies, diet aids, or other migraine medications.