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The following information outlines crucial safety warnings and potential risks associated with the use of this medication. Please read carefully and consult your healthcare provider with any concerns.

• High Potassium Levels (Hyperkalemia): Eplerenone (Inspra) may lead to elevated potassium levels in the blood, which can disrupt heart rhythm and, in severe cases, result in cardiac arrest. Individuals with kidney problems, diabetes, or those using certain other medications (such as ACE inhibitors, ARBs, or NSAIDs) are at an increased risk. If you experience sudden numbness, tingling, nausea, or muscle weakness, contact your healthcare provider immediately, as a dosage adjustment might be necessary.

• Contraindications: This medication should not be used in the following situations, as it can lead to serious health complications:

  • Presence of very high potassium levels.
  • Severe kidney impairment.
  • Concurrent use of particular drugs such as ketoconazole, ritonavir (Norvir), or clarithromycin.

For individuals with high blood pressure, additional contraindications include:

• Type 2 diabetes with elevated urine protein levels (microalbuminuria).
• Moderate to severe kidney issues.
• Concurrent use of potassium supplements or potassium-sparing diuretics like spironolactone (Aldactone), amiloride (Midamor), or triamterene (Dyrenium).

If any of these conditions apply to you, it is essential to speak with your healthcare provider before starting this medication to ensure your safety.

Common side effects:

• Headaches
• Dizziness
• Diarrhea
• Vomiting
• Digestive issues
• Nervous system problems
• Urinary tract discomfort
• Shortness of breath
• Skin reactions
• Mental health changes
• Cough

Less common but important to monitor:

• Chest pain
• Heart attack
• Gynecomastia
• Abnormal vaginal bleeding

Serious side effects:

• High potassium levels
• Muscle weakness
• Slow or irregular heartbeat
• Nausea
• Numbness or tingling
• Very serious allergic reaction
• Rash
• Itching or swelling
• Severe dizziness
• Trouble breathing

Interactions with high risk of serious adverse effects and should be avoided:

• Amiloride
• Clarithromycin
• Cobicistat
• Itraconazole
• Ketoconazole
• Spironolactone
• Triamterene
• Lithium
• Nelfinavir
• Ritonavir

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Adagrasib
• Nefazodone
• St. John's wort
• Telithromycin
• Licorice

Interactions with low risk that usually do not require a change in therapy:

• Ibuprofen
• Naproxen