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Eplerenone

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This medication is used alone or in combination with other medicines to treat high blood pressure. It works by blocking a chemical (aldosterone) in your body which in turn lowers the amount of sodium and water the body retains. Lowering high blood pressure helps prevent strokes, heart attacks and kidney problems. It is also used to treat heart failure following a heart attack.
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25MG, Eplerenone (30 Tablets)

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CVS

$23.70

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$16.60

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$16.90

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$26.94

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$30.49

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Eplerenone Side Effects

Headache, dizziness, diarrhea, or vomiting may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: abnormal vaginal bleeding, enlarged or sore breasts in males, symptoms of a high potassium blood level (such as muscle weakness, slow/irregular heartbeat). A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Interactions

Some of the products that may interact with this drug include: drugs that may increase the level of potassium in the blood (such as birth control pills containing drospirenone, potassium sparing water pills such as amiloride/spironolactone/triamterene), lithium. Other medications can affect the removal of eplerenone from your body, which may affect how eplerenone works. Examples include adagrasib, certain azole antifungals (such as ketoconazole, itraconazole), clarithromycin, cobicistat, nefazodone, certain HIV protease inhibitors (such as nelfinavir), ritonavir, St. John's wort, telithromycin, among others. Some products have ingredients that could raise your blood pressure or worsen your heart failure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen).
Eplerenone FAQs
What is eplerenone prescribed for?

Eplerenone is prescribed primarily for the treatment of high blood pressure (hypertension) and heart failure, particularly after a heart attack. It helps to lower blood pressure and reduce the risk of heart failure-related complications.

Spironolactone and eplerenone are both aldosterone antagonists used to treat conditions like heart failure and hypertension. The primary difference between the two lies in their selectivity and side effect profiles. Eplerenone is more selective for the mineralocorticoid receptor, which generally results in fewer side effects related to hormonal imbalances, such as gynecomastia and menstrual irregularities, compared to spironolactone. Spironolactone, being less selective, can affect other steroid receptors, leading to these additional side effects.

Eplerenone should not be taken with certain medications due to potential interactions. These include:1. Potassium supplements or potassium-sparing diuretics, as they can increase the risk of hyperkalemia (high potassium levels).2. Strong CYP3A4 inhibitors, such as ketoconazole, itraconazole, and clarithromycin, which can increase eplerenone levels in the blood.3. ACE inhibitors or angiotensin II receptor blockers (ARBs) may also increase the risk of hyperkalemia when used together with eplerenone.It is important for individuals to consult with their healthcare provider before starting or stopping any medications while taking eplerenone.

A suitable replacement for spironolactone depends on the condition being treated. For hypertension or heart failure, alternatives might include other diuretics like eplerenone, which is also a potassium-sparing diuretic. For acne or hormonal issues, options could include oral contraceptives or anti-androgens like flutamide. It's important for the patient to consult with their healthcare provider to determine the most appropriate alternative based on their specific medical needs and history.

A major adverse effect of eplerenone is hyperkalemia, which is an elevated level of potassium in the blood. This condition can be serious and requires monitoring, especially in patients with renal impairment or those taking other medications that increase potassium levels.

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