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The following safety information outlines important warnings associated with the use of doxycycline hyclate. Carefully review these points and consult your healthcare provider if you have any questions or concerns.

• Permanent Tooth Discoloration: Doxycycline hyclate, a tetracycline antibiotic, can cause permanent tooth discoloration, including yellow, gray, or brown staining in children under 8 years old. It may also result in enamel hypoplasia and affect dental development. Pregnant women and nursing mothers should avoid using this medication unless absolutely necessary due to a life-threatening infection. Discuss potential risks with your healthcare provider if you fall into these categories.

• Severe Diarrhea: Antibiotics like doxycycline hyclate can lead to Clostridium difficile-associated diarrhea (C. diff), which may occur during or up to two months post-treatment. This condition can become life-threatening if untreated. Contact your healthcare provider immediately if you experience diarrhea, fever, stomach pain, nausea, vomiting, or loss of appetite. Individuals at higher risk include those using multiple antibiotics, long-term antibiotic users, older adults, and those with a history of colon or gut issues.

• Severe Skin Reactions: Rare but severe skin reactions, including painful, blistering rashes, may develop. Seek medical attention if you notice a new rash, unexplained blisters, or sores, especially if accompanied by a fever.

• Intracranial Hypertension: Doxycycline hyclate can cause increased brain pressure (intracranial hypertension), with higher risk in overweight women of childbearing age or those with a history of this condition. Combined use with isotretinoin (Absorica) increases the risk. Symptoms include headaches, dizziness, vision changes, and swelling inside the eye. Contact your healthcare provider if you experience these symptoms.

• Harm to Unborn and Young Babies: Pregnant women should avoid doxycycline hyclate due to potential harm to the unborn baby's teeth and bone development. It may also affect bone growth in premature infants. Discuss use with your healthcare provider if you are pregnant or planning to become pregnant.

• Sun Sensitivity: Doxycycline hyclate increases skin sensitivity to sunlight, raising the risk of sunburn. Use protective clothing and sunscreen, and avoid tanning beds. Discontinue use and inform your provider if you experience skin redness or irritation.

• Esophageal Damage: Take doxycycline hyclate with plenty of water and remain upright for at least 30 minutes post-ingestion to prevent esophageal irritation or ulcers. Report any throat or chest pain to your provider.

• New Infections: Prolonged use of doxycycline hyclate can lead to bacterial or fungal overgrowth, causing new infections like vaginal yeast infections. Do not exceed the prescribed duration and notify your provider of any infection symptoms.

• Drug-Resistant Bacteria: Use doxycycline hyclate only for bacterial infections to prevent the development of drug-resistant bacteria, which are more challenging to treat. Avoid using antibiotics when unnecessary.

Common side effects:

• Stomach upset
• Nausea
• Vomiting
• Loss of appetite
• Increased sensitivity to sunlight

Less common but important to monitor:

• Diarrhea
• Swollen tongue
• Trouble swallowing
• Intestinal inflammation
• Vaginal yeast infection
• Rash

Serious side effects:

• Severe diarrhea with watery or bloody stools
• Pseudotumor cerebri
• Severe allergic reaction
• Serious skin reactions with fever, muscle aches, or blistering skin

Interactions with high risk of serious adverse effects and should be avoided:

• Acitretin

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Isotretinoin
• Methotrexate
• Penicillins (Amoxicillin, Ampicillin, Bacampicillin, Cloxacillin, Dicloxacillin, Methicillin, Nafcillin, Oxacillin, Penicillin G, Penicillin G Benzathine, Penicillin G Procaine, Penicillin V, Piperacillin, Pivampicillin, Sultamicillin, Temocillin)
• Contraceptives (Desogestrel, Dienogest, Drospirenone, Estradiol, Ethinyl Estradiol, Ethynodiol, Gestodene, Levonorgestrel, Mestranol, Nomegestrol, Norethindrone, Norgestimate, Norgestrel)

Interactions with low risk that usually do not require a change in therapy:

• Calcium
• Magnesium supplements
• Iron
• Certain antacids (Aluminum Carbonate, Basic, Aluminum Hydroxide, Aluminum Phosphate, Bismuth Subsalicylate, Dihydroxyaluminum Aminoacetate, Dihydroxyaluminum Sodium Carbonate, Magaldrate, Magnesium Carbonate, Magnesium Hydroxide, Magnesium Oxide, Magnesium Trisilicate)