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This medication carries important safety information regarding potential risks and should be reviewed carefully. Consult your healthcare provider if you have any concerns.

• Risk of Blood Clots, Heart Attack, and Stroke: Norethindrone acetate (Aygestin) may increase the risk of developing blood clots, which can be life-threatening if they travel to the lungs (causing a pulmonary embolism), heart (causing a heart attack), or brain (resulting in a stroke). Individuals with a personal or family history of blood clots, high blood pressure, diabetes, high cholesterol, obesity, or lupus, and those who smoke are at a higher risk.

• Vision Changes: This medication can lead to sudden vision changes, including double vision or loss of vision. Immediate consultation with a healthcare provider is necessary if such symptoms occur, as an eye examination may be required to determine if medication discontinuation is needed.

• Fluid Retention (Edema): There is a possibility of fluid retention, causing swelling in the hands, feet, ankles, or stomach. This can exacerbate conditions such as seizures, migraines, heart, or kidney problems. Contact your healthcare provider if you observe any swelling or deterioration in health conditions.

• Depression: Norethindrone acetate (Aygestin) may aggravate depression symptoms in those with a history of depression. Symptoms include persistent sadness, loss of interest in activities, appetite changes, fatigue, sleep issues, and feelings of worthlessness. It is crucial to inform your healthcare provider of any past depression before starting this medication and report any changes in mood or behavior.

• Blood Sugar and Cholesterol Changes: This medication can affect blood sugar levels, particularly in individuals with diabetes. It is important to inform your healthcare provider if you have diabetes, as they may recommend more frequent monitoring or adjustments to diabetes medications.

• Risk to Unborn Baby: Taking norethindrone acetate (Aygestin) during pregnancy can harm an unborn baby and increase the risk of birth defects, especially in the first four months. Do not take this medication if pregnant or suspect you might be. Notify your healthcare provider immediately if you become pregnant while on this medication.

Contraindications:

Norethindrone acetate (Aygestin) should be avoided under the following conditions due to serious health risks. Consult your healthcare provider if any apply to you:

• Current or suspected pregnancy
• Undiagnosed vaginal bleeding
• Known or suspected breast cancer history
• Current or past blood clots
• Recent or active stroke or heart attack
• Liver damage or disease
• Using this medication to diagnose pregnancy

When taking this medication, you might experience some common side effects such as nausea, vomiting, headaches, dizziness, mood swings, trouble sleeping, or changes in weight. Acne, breast tenderness, and changes in sexual interest or hair growth are also possible. These effects are generally mild, but you should consult your healthcare provider if they persist or worsen.

There are also more serious side effects to be aware of, including changes in menstrual flow, such as breakthrough bleeding or spotting, absence of periods, and changes in vaginal discharge. Depression, swelling of the hands and feet, or yellowing of the skin or eyes (jaundice) have been reported and require prompt medical attention if they occur.

Rarely, this medication can lead to severe problems like blood clots, which can cause heart attacks, strokes, or pulmonary embolisms. Symptoms of these conditions include sudden chest pain, difficulty speaking, severe headaches, shortness of breath, or swelling and pain in the legs. Seek immediate medical help if you experience any of these symptoms.

Although very rare, severe allergic reactions can occur, characterized by symptoms such as rash, severe dizziness, swelling of the face or throat, or trouble breathing. Immediate medical attention is critical in these cases. Always communicate with your healthcare provider about any side effects you experience, even those not listed here, to ensure your safety and well-being.

Norethindrone can be affected by other medications, which may alter its effectiveness. For example, antifungal medications like Itraconazole, antibiotics such as Rifampin, herbal supplements like St. John's wort, and seizure medications including [Carbamazepine](https://savehealth.com/carbamazepine) and Phenytoin can influence how norethindrone works by changing how it is removed from your body.

Norethindrone acetate, also known as Aygestin, has the potential to interact with various medications and supplements. It is important to inform your healthcare provider about all the medications and supplements you are taking, whether they are prescribed, over-the-counter, vitamins, or herbal supplements. Some interactions are not recommended, such as with boceprevir, Dofetilide, and Tranexamic Acid. In some cases, using norethindrone with certain drugs like abametapir, amobarbital, and carbamazepine may be necessary, but this requires careful monitoring and possible dose adjustments by your doctor. Additionally, norethindrone may affect lab test results, so ensure your healthcare team is aware that you are using this medication.