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Roflumilast

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generic Daliresp, Zoryve

Roflumilast, known by its brand name Daliresp, is an oral medication used for the maintenance treatment of severe chronic obstructive pulmonary disease (COPD), including conditions like bronchitis. It is designed to control and prevent symptoms such as wheezing and shortness of breath by reducing airway irritation and inflammation. This medication belongs to a class of drugs called phosphodiesterase-4 (PDE-4) inhibitors, which work by blocking a protein that causes lung inflammation, thereby helping to open the airways and improve breathing. Roflumilast is not intended for immediate relief of sudden breathing problems; instead, it should be used regularly in combination with other medications, such as bronchodilators, to effectively manage COPD symptoms and reduce the risk of flare-ups. It is taken once daily in tablet form. Common side effects include diarrhea, nausea, and weight loss. Always consult with a healthcare provider for advice tailored to your individual needs before starting any new medication.
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Roflumilast WarningsRoflumilast Side EffectsRoflumilast InteractionsFAQs

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250MCG, Roflumilast (30 Tablets)

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$53.07

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$98.82

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$118.95

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Roflumilast dosage forms

The average cost for 30 Tablets of Roflumilast (generic Daliresp, Zoryve) at 500MCG is $13.63 with a free coupon. This is 2.93% off the average retail price of $465.3
DosageQuantityPrice fromPer unit
500MCG30 Tablets$13.63$0.45
250MCG30 Tablets$53.76$1.79

Roflumilast Warnings

The safety and warning information provided here is crucial for understanding the potential risks associated with the use of this medication. Please review these details carefully and discuss any concerns with your healthcare provider.

  • Not for Acute COPD Symptoms: Roflumilast (Daliresp) should not be used for the immediate relief of sudden COPD symptom exacerbations. It is not a rescue medication. In cases of a COPD flare-up, use your prescribed rescue inhaler for rapid relief.

  • Mood and Behavior Changes: This medication may increase the risk of mood alterations, including insomnia, anxiety, and depression. Although infrequent, some individuals have experienced suicidal thoughts or behaviors. This risk is heightened in those with a history of mental health issues.

  • Weight Loss: A common side effect of roflumilast (Daliresp) is weight loss. Clinical studies have shown that some individuals lost between 5% to 10% or more of their body weight after a year of usage. Most regained the weight after discontinuing the medication.

  • Drug Interactions: Roflumilast (Daliresp) may interact with various medications, potentially reducing its effectiveness in managing COPD. Medications such as rifampin, carbamazepine (Tegretol), and phenytoin (Dilantin) can decrease the levels of roflumilast in the body.

Contraindications: The use of this medication is not advised for individuals with moderate or severe liver problems due to potential serious health risks. Consult your healthcare provider if this applies to you.

In case of an overdose, seek emergency medical attention immediately.

Roflumilast Side Effects

Common side effects:

  • Diarrhea
  • Weight loss
  • Nausea
  • Headache
  • Dizziness
  • Loss of appetite
  • Upset stomach
  • Difficulty sleeping
  • Back pain
  • Runny nose
  • Sinus inflammation
  • Flu-like symptoms
  • Muscle spasms

Less common but important to monitor:

  • Fast or irregular heartbeat
  • Trouble sleeping

Serious side effects:

  • Anxiety
  • Depression
  • Suicidal thoughts or behavior
  • Tremors
  • Allergic reaction (rash, itching, swelling, severe dizziness, difficulty breathing)

Roflumilast Interactions

Interactions with high risk of serious adverse effects and should be avoided:

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

Roflumilast FAQs
What type of medication is roflumilast?

Roflumilast is a phosphodiesterase-4 (PDE4) inhibitor. It is used to reduce the risk of exacerbations in patients with severe chronic obstructive pulmonary disease (COPD) associated with chronic bronchitis and a history of exacerbations.

Roflumilast may cause several side effects. Common side effects include diarrhea, weight loss, nausea, headache, and back pain. Some individuals may also experience insomnia, dizziness, or decreased appetite. It is important to monitor for any severe reactions such as mood changes, depression, or suicidal thoughts, and report these to a healthcare provider immediately. As with any medication, if any unusual or severe side effects occur, it is advisable to seek medical attention.

Roflumilast improves breathing by reducing inflammation in the airways. It is a phosphodiesterase-4 (PDE4) inhibitor, which helps decrease the frequency of flare-ups or worsening of symptoms in individuals with severe chronic obstructive pulmonary disease (COPD). By targeting the inflammatory process, it helps to relax the airways and improve airflow, making it easier to breathe.

Yes, DALIRESP is the brand name for the medication roflumilast. They are the same medication.

The generic version of DALIRESP is roflumilast.

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