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Naproxen, a nonsteroidal anti-inflammatory drug (NSAID), carries several important safety warnings and precautions. Understanding these risks can help ensure safe use of the medication. Please consult your healthcare provider if you have any questions or concerns.

• Heart Attack and Stroke Risk: Taking naproxen may increase your risk of heart attack or stroke, especially if used long-term or at higher doses. This risk is heightened in individuals with existing heart conditions. Do not use naproxen immediately before or after heart surgery, such as coronary artery bypass graft (CABG) surgery. Seek immediate medical assistance if you experience symptoms like chest pain, shortness of breath, or sudden weakness.

• Stomach and Intestinal Bleeding: Naproxen can cause severe stomach or intestinal bleeding, which may occur without warning. This risk is higher in older adults, those with a history of stomach ulcers or bleeding, liver problems, or individuals who consume alcohol or smoke. If you notice symptoms such as persistent stomach pain, black or bloody stools, or vomit that resembles coffee grounds, seek medical attention immediately.

• High Blood Pressure and Heart Failure: Naproxen may cause fluid retention, potentially leading to elevated blood pressure or heart failure. Inform your healthcare provider of any heart conditions or if you are on blood pressure medication before starting naproxen. Watch for symptoms like unexplained fainting, chest pain during physical activity, or an irregular heartbeat.

• Kidney Damage: The use of naproxen can lead to kidney issues, particularly in those with pre-existing kidney problems, diabetes, or dehydration. Your healthcare provider may conduct tests to monitor kidney function during treatment. Report any changes in urination, fatigue, dry skin, or muscle cramps to your healthcare professional promptly.

• Liver Problems: Rarely, naproxen can cause serious liver damage. Symptoms of liver issues include stomach swelling, yellowing of the skin or eyes, dark urine, and confusion. If these occur, seek medical help immediately and discontinue use.

• Severe Allergic Reactions: Allergic reactions to naproxen, such as anaphylaxis, can be life-threatening. Symptoms include hives, facial swelling, difficulty breathing, or rash. Individuals with known allergies to NSAIDs or aspirin should avoid naproxen.

• Pregnancy and Breastfeeding: Naproxen is not recommended for use during pregnancy, especially after 20 weeks, due to potential risks to the unborn baby. Discuss alternatives with your healthcare provider if you are pregnant or breastfeeding.

• Contraindications: Do not use naproxen if you have a history of asthma or allergic reactions to NSAIDs, or if you are scheduled for or recovering from coronary artery bypass graft surgery.

Always discuss the benefits and potential risks of naproxen with your healthcare provider to determine the best treatment plan for your condition.

When taking this medication, some individuals may encounter common side effects like upset stomach, nausea, heartburn, headache, drowsiness, dizziness, stomach pain, constipation, itchy skin, and mild bruising. These are generally mild, but if they persist, consulting a healthcare provider is advisable. Additionally, an increase in blood pressure may occur, so regular monitoring is recommended.

Other reported side effects include indigestion, diarrhea, sweating, mouth sores, a racing heart, a spinning sensation, increased thirst, and changes in hearing. Although uncommon, these symptoms should be brought to the attention of your healthcare provider, especially if they are severe.

Serious side effects, which are rare but require immediate medical attention, include symptoms of stomach bleeding, heart attack, stroke, and heart failure. These can manifest as chest pain, trouble breathing, severe stomach pain, or changes in vision. Additionally, worsening liver or kidney problems, characterized by yellowing of the skin, dark urine, or reduced urination, warrant urgent care. Rare allergic reactions and serious skin reactions may present as hives, blisters, or difficulty breathing, and should also prompt immediate medical consultation.

While this summary covers many potential side effects, it is not exhaustive. If you notice any unusual symptoms or reactions, contact your healthcare provider promptly for advice.

When taking Naproxen, be aware that it can interact with several other medications. Some medicines, such as Ketorolac, should not be used with naproxen. Others, like abciximab, Amiloride, Citalopram, and Lithium, may be used together only under close medical supervision as they might require dose adjustments or monitoring due to potential interactions.

Naproxen may enhance the risk of bleeding, especially when combined with medications like Clopidogrel, Warfarin, or other blood thinners. Additionally, drugs like Furosemide and certain corticosteroids may interact with naproxen, potentially affecting their effectiveness or increasing side effects.

It is crucial to avoid taking naproxen with antacids or drugs that lower stomach acid, such as Omeprazole, since they can disrupt the drug's enteric coating, leading to premature release and increased side effects. If you're using low-dose Aspirin for heart protection, continue only if advised by your doctor, as naproxen may reduce aspirin’s efficacy in preventing heart attacks or strokes.

Always inform your healthcare provider about all medications, including over-the-counter drugs, vitamins, and supplements, to ensure safe and effective use of naproxen.