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Oxaprozin, a nonsteroidal anti-inflammatory drug (NSAID), has associated safety risks and warnings that require careful consideration. Below are important points to be aware of before using this medication:

• Heart Attack and Stroke Risk: Oxaprozin may elevate the risk of heart attack or stroke, which can occur at any time during treatment and is more likely with prolonged use. This risk is heightened in older adults and individuals with heart disease or risk factors such as smoking, high blood pressure, or diabetes. Avoid taking oxaprozin before or after heart bypass surgery. Seek immediate medical help if you experience symptoms like chest pain, shortness of breath, weakness on one side of the body, or difficulty speaking.

• Stomach and Intestinal Bleeding: This medication can cause severe, sometimes fatal, bleeding in the stomach or intestines without prior symptoms. The risk is higher in older adults, those with a history of stomach bleeding, or those taking other medications that increase bleeding risk. Watch for symptoms like persistent stomach pain, bloody or black stools, or vomit resembling coffee grounds, and seek medical attention immediately if they occur.

• Blood Pressure and Heart Failure: Oxaprozin can cause fluid retention, potentially leading to increased blood pressure or heart failure. Inform your healthcare provider of any heart conditions or if you are on blood pressure medication prior to starting oxaprozin. Contact your provider if you notice unexplained fainting, chest pain during activity, or an irregular heartbeat.

• Kidney Damage: The use of oxaprozin may result in kidney problems, especially in older adults or those with pre-existing conditions like diabetes. Regular blood tests may be required to monitor kidney function. Report any symptoms of kidney issues, such as changes in urination, fatigue, dry skin, or muscle cramps, to your provider.

• Liver Problems: Although rare, oxaprozin can cause liver damage. Look for symptoms such as abdominal swelling, jaundice, changes in stool color, nausea, vomiting, confusion, or dark urine. Immediate medical attention is necessary if these symptoms appear.

• Severe Allergic Reactions: Some individuals may experience severe allergic reactions, including anaphylaxis. Notify your provider if you have a known allergy to aspirin or other NSAIDs. Seek emergency medical help if you develop symptoms like hives, rash, facial swelling, or difficulty breathing.

• Pregnancy and Breastfeeding: Oxaprozin is not recommended for pregnant or breastfeeding women without consulting a healthcare provider, as it may harm the unborn baby or cause complications during delivery if used in the latter half of pregnancy.

• Contraindications: Do not use oxaprozin if you have a history of asthma, hives, or allergic reactions to aspirin or other NSAIDs, or if you have undergone coronary artery bypass graft surgery.

Always discuss the potential risks and benefits of oxaprozin with your healthcare provider before starting treatment.

Common side effects:

• upset stomach
• constipation
• diarrhea
• nausea
• vomiting
• gas
• headaches
• dizziness
• drowsiness

Less common but important to monitor:

• changes in vision
• changes in hearing
• mood alterations
• easy bruising or bleeding
• signs of kidney issues
• increase in blood pressure

Serious side effects:

• symptoms of liver damage
• symptoms of heart problems
• allergic reactions

Interactions with high risk of serious adverse effects and should be avoided:

• Ketorolac

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Warfarin
• Enoxaparin
• Dabigatran
• Clopidogrel
• Methotrexate
• Lithium
• Diuretics such as Furosemide
• NSAIDs such as Ibuprofen, Celecoxib