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Oxaprozin, a nonsteroidal anti-inflammatory drug (NSAID), may infrequently elevate the risk of heart attack or stroke. This risk can arise at any stage of treatment but is more pronounced with prolonged use. The likelihood is higher in older adults or individuals with existing heart conditions, or risk factors such as smoking, a family history of heart disease, high blood pressure, or diabetes. It is crucial to avoid using this medication immediately before or after coronary artery bypass graft (CABG) surgery.

Additionally, oxaprozin may occasionally lead to serious, potentially fatal gastrointestinal bleeding. This can occur without prior symptoms at any point during medication use, with older adults being more susceptible.

Be vigilant for the following rare but severe symptoms, and discontinue use while seeking immediate medical attention if they occur:

• Persistent stomach or abdominal pain
• Bloody or black, tarry stools
• Vomit that resembles coffee grounds
• Chest, jaw, or left arm pain
• Shortness of breath
• Unusual sweating
• Weakness on one side of the body
• Sudden changes in vision
• Difficulty speaking

Consult your doctor or pharmacist to thoroughly understand the risks and benefits associated with using this medication.

You might experience mild side effects such as an upset stomach, constipation, diarrhea, nausea, vomiting, gas, heartburn, drowsiness, dizziness, or headache. These are generally not serious, but if they persist or worsen, it is important to consult your healthcare provider.

A potential concern with this medication is its effect on blood pressure, which may elevate. Regular monitoring of your blood pressure is advisable, and any significant increases should be discussed with your healthcare provider.

More serious side effects, although less common, require immediate medical attention. These include vision or hearing changes, mood alterations, signs of kidney issues (like changes in urine output), unusual bruising or bleeding, and symptoms indicative of heart failure, such as swollen ankles, unusual fatigue, or sudden weight gain.

While rare, this medication can lead to severe liver damage, which could be life-threatening. Seek emergency care if you experience persistent nausea or vomiting, loss of appetite, dark urine, severe abdominal pain, or yellowing of the skin or eyes.

Allergic reactions to this drug are also rare but serious. If you notice symptoms such as fever, swollen lymph nodes, rash, itching, swelling (particularly of the face, tongue, or throat), severe dizziness, or difficulty breathing, immediate medical help is necessary.

This summary does not cover all possible side effects. If you observe other unexpected effects, please reach out to your healthcare provider for guidance.