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While taking this medication, you may experience some mild side effects like dizziness, drowsiness, weakness, blurred vision, dry eyes, dry mouth, nausea, constipation, or abdominal bloating. These are generally manageable and often improve as your body adjusts. To alleviate dry mouth, try sugarless candy or gum, ice chips, water, or saliva substitutes. For dry eyes, artificial tears or eye lubricants can be helpful. To prevent constipation, incorporate fiber into your diet, stay hydrated, and exercise regularly; a pharmacist can recommend a suitable laxative if needed.

However, some side effects may require immediate medical attention. Contact your doctor if you notice severe effects such as decreased sweating, dry or flushed skin, fast or irregular heartbeat, loss of coordination, trouble speaking, fainting, or mood changes including confusion or depression. Additionally, seek help if you experience difficulty urinating, decreased sexual ability, signs of anemia, or easy bruising.

In rare cases, serious side effects such as eye pain, vision changes, or slow and shallow breathing might occur, necessitating urgent care. Although very rare, allergic reactions can happen. Symptoms to watch for include fever, swollen lymph nodes, rash, severe dizziness, or trouble breathing. Always consult your healthcare provider if you observe any new or concerning symptoms not listed here.

This drug can interact with several other products, including Darunavir, potassium supplements, Sodium Oxybate, and medications like pramlintide that are impacted by slower gut movement. It might also influence the absorption of certain medications, such as griseofulvin, some antifungal drugs like Ketoconazole and Itraconazole, and slow-release forms of Digoxin.

Certain drugs, like St. John's wort, can alter how your body removes Phenobarbital, which might change its effectiveness. Conversely, phenobarbital can hasten the elimination of other medicines, affecting their efficacy. This includes drugs like artemether/lumefantrine, asunaprevir, Atazanavir, cobicistat, Etravirine, Lurasidone, ranolazine, rilpivirine, sofosbuvir, Sorafenib, Voriconazole, and some calcium channel blockers such as felodipine and Nimodipine.

Phenobarbital may reduce the effectiveness of hormonal birth control methods, such as pills, patches, or rings, potentially leading to pregnancy. It's important to talk to your doctor or pharmacist about using additional reliable birth control methods while on this medication. Notify your doctor if you experience any new spotting or breakthrough bleeding, as these may indicate your birth control is not fully effective.

Taking this drug with products that also cause drowsiness or breathing issues can increase the risk of serious side effects like slow or shallow breathing and severe drowsiness or dizziness. Inform your doctor or pharmacist if you’re using products like opioid painkillers or cough suppressants (e.g., codeine, hydrocodone), alcohol, marijuana, sleep or anxiety medications (e.g., Alprazolam, Lorazepam, Zolpidem), muscle relaxants (e.g., Carisoprodol, Cyclobenzaprine), or antihistamines (e.g., Cetirizine, diphenhydramine).

Check the labels on your medicines, especially allergy or cold remedies and diet aids, as they may contain ingredients that cause drowsiness or a rapid heartbeat. Consult your pharmacist to use these products safely.

Phenobarbital is similar to Primidone; avoid using medications containing primidone while taking phenobarbital. This drug may also interfere with certain lab tests, like gastric secretion tests, leading to inaccurate results. Ensure your doctors and lab personnel are aware that you are using this medication.