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Common side effects of this medication can include dizziness, drowsiness, weakness, blurred vision, dry eyes, dry mouth, nausea, constipation, and abdominal bloating. These effects are usually mild and often improve as your body adjusts to the medication. To alleviate dry mouth, consider using sugarless hard candy or gum, sipping water, or trying a saliva substitute. For dry eyes, artificial tears or other eye lubricants might be helpful. To prevent constipation, incorporate dietary fiber, stay hydrated, and engage in regular physical activity. A suitable laxative may also be recommended by your pharmacist.

While severe side effects are less common, it is important to be aware of them. Contact a healthcare provider immediately if you experience decreased sweating, dry or flushed skin, a rapid or irregular heartbeat, loss of coordination, difficulty speaking, fainting, mood changes, trouble urinating, reduced sexual function, signs of anemia, or easy bruising or bleeding. Urgent medical attention is necessary if you notice very serious symptoms such as eye pain, swelling, redness, changes in vision, or breathing difficulties.

Allergic reactions are rare but can be serious. Seek immediate medical help if you experience symptoms like fever, swollen lymph nodes, rash, severe dizziness, or swelling, especially of the face, tongue, or throat. Remember, this is not a comprehensive list of side effects. If you experience any unusual symptoms, consult your healthcare provider for guidance.

Certain medications and products can interact with this drug. These include Darunavir, potassium supplements, Sodium Oxybate, and medications like pramlintide that are affected by slower digestion. This drug may alter the absorption of other medications such as griseofulvin, certain antifungal drugs (Ketoconazole, Itraconazole), and slow-release forms of Digoxin. Additionally, other medicines such as St. John's wort can influence how Phenobarbital is removed from the body, potentially affecting its effectiveness.

Phenobarbital can also speed up the removal of other drugs, which might change how they work. This includes medications like artemether/lumefantrine, asunaprevir, Atazanavir, cobicistat, Etravirine, Lurasidone, ranolazine, rilpivirine, sofosbuvir, Sorafenib, Voriconazole, and some calcium channel blockers like felodipine and Nimodipine. This medication might reduce the effectiveness of hormonal contraceptives such as pills, patches, or rings, which could result in pregnancy. It is important to talk to your doctor or pharmacist about using additional birth control methods. Notify your doctor if you experience any new spotting or breakthrough bleeding, as these could indicate that your birth control is not working effectively.

The risk of severe side effects, such as slow or shallow breathing and significant drowsiness or dizziness, may increase if this medication is taken with other products that cause drowsiness or breathing issues. Inform your doctor if you consume opioid painkillers or cough suppressants (like codeine, hydrocodone), alcohol, marijuana, sleep or anxiety medications (such as Alprazolam, Lorazepam, Zolpidem), muscle relaxants (like Carisoprodol, Cyclobenzaprine), or antihistamines (such as Cetirizine, diphenhydramine).

Examine the labels of all your medicines (such as allergy, cough-and-cold products, and diet aids) since they may have ingredients that cause drowsiness or a rapid heartbeat. Consult your pharmacist on how to use these products safely. Avoid using medications containing Primidone while taking phenobarbital, as they are very similar. This medication might interfere with certain laboratory tests, such as those measuring stomach acid, potentially leading to incorrect test results. Ensure that laboratory personnel and all your healthcare providers are aware that you are using this medication.