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Common side effects:

• dizziness
• drowsiness
• weakness
• blurred vision
• dry eyes
• dry mouth
• nausea
• constipation

• abdominal bloating

  Less common but important to monitor:

• decreased sweating
• dry or hot skin
• fast or irregular heartbeat
• loss of coordination
• trouble speaking
• fainting
• mood changes like confusion or agitation
• difficulty urinating
• decreased sexual ability
• symptoms of anemia such as unusual fatigue and pale skin

• easy bruising or bleeding

  Serious side effects:

• eye pain
• swelling
• redness
• vision changes
• slow and shallow breathing
• allergic reaction symptoms like fever, swollen lymph nodes, rash, itching, swelling (particularly of the face, tongue, or throat), severe dizziness, and trouble breathing

Phenobarbital may interact with several other medications and substances. It is important to be aware of these interactions:

1. Potential Interacting Products: Some drugs that may interact with phenobarbital include Darunavir, potassium supplements, sodium oxybate, and medications that are influenced by slowed digestion, such as pramlintide.

2. Absorption Interference: Phenobarbital can affect the absorption of certain drugs, including griseofulvin, azole antifungals like Ketoconazole and Itraconazole, and slow-release forms of Digoxin.

3. Impact on Drug Removal: Certain medications, such as St. John's wort, can alter the removal of phenobarbital from your body, potentially influencing its effectiveness. Conversely, phenobarbital can accelerate the elimination of other drugs, which might reduce their efficacy. This includes medications like artemether/lumefantrine, Atazanavir, cobicistat, etravirine, Lurasidone, ranolazine, rilpivirine, sofosbuvir, sorafenib, Voriconazole, and some calcium channel blockers (for example, felodipine and Nimodipine).

4. Hormonal Birth Control: Phenobarbital may reduce the effectiveness of hormonal contraceptives, such as pills, patches, or rings, increasing the risk of pregnancy. Consider discussing alternative birth control methods with your healthcare provider and report any unusual spotting or breakthrough bleeding.

5. Increased Side Effects Risk: Taking phenobarbital alongside other substances that cause drowsiness or breathing issues can heighten the risk of severe side effects, including slow or shallow breathing and extreme drowsiness. Be cautious if you're using opioid pain relievers, alcohol, cannabis, sleep or anxiety medications, muscle relaxants, or antihistamines.

6. Label Caution: Always check the labels of over-the-counter products, like allergy remedies or diet aids, as they may contain ingredients that could cause drowsiness or a rapid heartbeat. Consult your pharmacist for safe usage advice.

7. Avoiding Primidone: Since phenobarbital is similar to primidone, avoid using both medications simultaneously.

8. Lab Test Interference: Phenobarbital might interfere with certain laboratory tests, leading to inaccurate results. Ensure all medical personnel are aware of your phenobarbital usage.

Always consult your doctor or pharmacist if you have any concerns about potential drug interactions.