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Common side effects:

• dizziness
• drowsiness
• weakness
• blurred vision
• dry eyes
• dry mouth
• nausea
• constipation

• abdominal bloating

  Less common but important to monitor:

• decreased sweating
• dry or hot skin
• fast or irregular heartbeat
• loss of coordination
• trouble speaking
• fainting
• mental or mood changes such as confusion or depression
• difficulty urinating
• decreased sexual ability
• signs of anemia like unusual tiredness or pale skin

• easy bruising or bleeding

  Serious side effects:

• eye pain or changes in vision
• slow or shallow breathing
• severe allergic reactions including fever, swollen lymph nodes, rash, itching, swelling, severe dizziness, and trouble breathing

Phenobarbital can interact with several other products and medications. It may interact with drugs like Darunavir, potassium tablets or capsules, sodium oxybate, and medications that are affected by slowed gut movement, such as pramlintide. Phenobarbital can alter the absorption of other medicines including griseofulvin, certain antifungal drugs like Ketoconazole and Itraconazole, as well as slowly dissolving forms of Digoxin.

Some medications, like St. John's wort, may affect how phenobarbital is removed from your body, potentially impacting its effectiveness. Conversely, phenobarbital can increase the elimination rate of other drugs, which might reduce their efficacy. These drugs include artemether/lumefantrine, Atazanavir, cobicistat, etravirine, Lurasidone, ranolazine, rilpivirine, sofosbuvir, sorafenib, Voriconazole, and certain calcium channel blockers such as felodipine and Nimodipine.

Phenobarbital may also reduce the effectiveness of hormonal birth control methods, like pills, patches, or rings, increasing the risk of pregnancy. It's important to discuss with your healthcare provider about using additional contraceptive methods. Notify your doctor if you experience any unusual spotting or breakthrough bleeding, as these may indicate that your birth control is less effective.

Taking phenobarbital with other substances that cause drowsiness or breathing difficulties can heighten the risk of severe side effects, such as slow or shallow breathing, and significant drowsiness or dizziness. Inform your healthcare provider if you are using opioid pain or cough relievers (e.g., codeine, Hydrocodone), alcohol, marijuana, other sleep or anxiety medications (e.g., Alprazolam, Lorazepam, Zolpidem), muscle relaxants (e.g., Carisoprodol, Cyclobenzaprine), or antihistamines (e.g., Cetirizine, diphenhydramine).

Check all your medications, including those for allergies, cough, cold, or diet, as they may contain ingredients that cause drowsiness or rapid heartbeat. Consult your pharmacist for safe usage of these products.

Avoid using medications containing Primidone while on phenobarbital, as they are very similar. Lastly, phenobarbital can interfere with certain laboratory tests, such as those assessing gastric secretion, potentially leading to inaccurate results. Ensure that all healthcare professionals involved in your care are aware that you are taking this medication.