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You may experience some common side effects such as dizziness, drowsiness, weakness, blurred vision, dry eyes, dry mouth, nausea, constipation, and abdominal bloating. These are usually mild and manageable. For dry mouth, try sugarless candy or gum, ice chips, drinking water, or a saliva substitute. Dry eyes can be eased with artificial tears or eye lubricants. To prevent constipation, consider increasing dietary fiber, staying hydrated, and regular exercise; a suitable laxative might also be recommended by your pharmacist.

While many people do not face severe side effects, it's important to be aware of them. Serious side effects requiring prompt medical attention include decreased sweating, dry or flushed skin, fast or irregular heartbeat, loss of coordination, trouble speaking, fainting, mental or mood changes (such as confusion or depression), difficulty urinating, decreased sexual ability, signs of anemia like unusual tiredness, and easy bruising or bleeding.

Seek immediate medical help for very serious issues like eye pain, swelling, redness, vision changes, or slow shallow breathing. Rarely, a severe allergic reaction may occur, characterized by fever, swollen lymph nodes, rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing. Always contact a healthcare professional if you notice any side effects not listed here.

Some medications and products can interact with this drug, including Darunavir, potassium supplements, Sodium Oxybate, and medications like pramlintide that are influenced by slower digestion. This drug might alter how other substances are absorbed, such as griseofulvin, certain antifungal medications (like Ketoconazole and Itraconazole), and slow-release forms of Digoxin. Additionally, certain drugs, including St. John's wort, can impact how your body processes Phenobarbital, affecting its effectiveness.

Phenobarbital can also accelerate the elimination of other medications, potentially reducing their effectiveness. These include artemether/lumefantrine, asunaprevir, Atazanavir, cobicistat, Etravirine, Lurasidone, ranolazine, rilpivirine, sofosbuvir, Sorafenib, Voriconazole, and some calcium channel blockers like felodipine and Nimodipine.

This medication may reduce the effectiveness of hormonal contraceptives such as pills, patches, and rings, possibly leading to pregnancy. Consult your doctor or pharmacist about using additional birth control methods and report any unusual spotting or bleeding, as these could indicate that your contraceptive is less effective.

Taking this drug with other products that cause drowsiness or breathing issues can increase the risk of severe side effects like shallow breathing or extreme drowsiness. Inform your doctor or pharmacist if you use opioids (such as codeine, hydrocodone), alcohol, cannabis, sleep or anxiety medications (such as Alprazolam, Lorazepam, Zolpidem), muscle relaxants (such as Carisoprodol, Cyclobenzaprine), or antihistamines (such as Cetirizine, diphenhydramine).

Check labels on all your medications, including those for allergies or colds, as they may have ingredients that cause drowsiness or rapid heartbeat. Consult your pharmacist for safe usage.

Phenobarbital is similar to Primidone; avoid using primidone-containing medications while on phenobarbital. This medication can interfere with certain lab tests, such as gastric secretion tests, possibly leading to incorrect results. Ensure that all your healthcare providers and lab personnel are aware of your phenobarbital usage.